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Gout Treatments

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turlough's version from 2017-10-30 01:20

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Question Answer
What class does allopurinol belong to? Xanthine oxidase inhibitors
2 indications for allopurinol.Gout. Hyperuricaemia.
Mechanism of allopurinol
When is a dose adjustment required for allopurinol? In renal impairment.
Does food affect the absorption of allopurinol? No
6 possible interactions with allopurinol Azathioprine and 6-mercaptopurine. Cytotoxics (e.g. cyclophosphamide). Diuretics. ACE inhibitors. Amoxicillin.
Explain the interaction between allopurinol and azathioprine/6-mercaptopurine and how it can be managed. The immunosuppressants azathioprine and 6-MP are metabolised and eliminated by xanthine oxidase. Since allopurinol inhibits this enzyme, concurrent use increases the risk of side-effects. The dose of the immunosupressant should be reduced.
Explain the interaction between allopurinol and diuretics. Loop diuretics and thiazide diuretics can cause hyperuricaemia so they reduce the efficacy of allopurinol.
Explain the interaction between allopurinol and ACE inhibitors. The combination of allopurinol and an ACE inhibitor appears to pose a greater risk of hypersensitivity, particularly in renal impairment.
Explain the interaction between allopurinol and amoxicillin. The combination of allopurinol and amoxicillin increases the risk of skin rash.
What is the most common side effect of allopurinol? Rash
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