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Glucagon

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paramedic's version from 2017-09-14 19:04

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Question Answer
Classification Hyperglycemia Agent, Beta Blocker OD Antidote, Hormone & Hormones modifier, Antihypoglycemic agent
Mechanism of Action Glucagon is a protein secreted by the Alpha cells of the pancreas which causes breakdown of stored glycogen to glucose therefore increasing blood glucose levels, Causes relaxation of smooth muscles of GI tract, Positive Inotropic/ Chronotropic effects, Decreases Renaldo Resistance.
IndicationsHypoglycemia w/ no IV line, GI Obstruction, Beta Blocker Overdose
ContraindicationsAdrenal Insufficiency / Pheochrocytoma, Hypersensitivity, Lactation, Malnutrition, Allergy to Sulfa
Side EffectsTachycardia, Hypertension, Anaphylaxis, Angina, Hypotension, Nausea/ Vomiting.
Routes of AdministrationIM / IV
Onset / Duration8-10 minutes IM
Adult Dose for Hypoglycemia1 mg IV or IM repeat every 5 - 20 minutes PRN
Adult Dose for Beta-Blocker Overdose3 - 10 mg slow IV over 3 to 5 minutes followed by an infusion of 3 - 5 mg / hour
Pediatric Dose for Hypoglycemia0.03 - 0.1 mg/Kg IM (Max 1 mg)
Pediatric Dose for Beta-Blocker Overdose2- 3 mg slow IV over 3 to 5 minutes followed by an infusion of 3- 5 mg / hour
Additional InfoMix 1 mg glucagon powder to dilutent supplied in kit. Precipitate will form if mixed with chloride solutions, so Use sterile water not saline to reconstitute the vial. Effectiveness is dependant on glycogen stores in the liver.
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