jatadescargas's version from 2016-02-16 15:58


Question Answer
Acute poststreptococcal glomerulonephritis LMLM—glomeruli enlarged and hypercellular
Acute poststreptococcal glomerulonephritis IFIF—(“starry sky”) granular appearance (“lumpy-bumpy”) B due to IgG, IgM, and C3 deposition along GBM and mesangium
Acute poststreptococcal glomerulonephritis EMEM—subepithelial immune complex (IC) humps.
Acute poststreptococcal glomerulonephritis RxResolves spontaneously. Type III hypersensitivity reaction.
Rapidly progressive (crescentic) glomerulonephritis LM and IFLM and IF—crescent moon shape C . Crescents consist of fibrin and plasma proteins (eg, C3b) with glomerular parietal cells, monocytes, macrophages.
Rapidly progressive (crescentic) Good Pasturetype II hypersensitivity; antibodies to GBM and alveolar basement membrane Ž linear IF
Granulomatosis with polyangiitis (Wegener)PR3-ANCA/c-ANCA. Pauci-immune (no Ig/C3 deposition).
Microscopic polyangiitisMPO-ANCA/p-ANCA. Pauci-immune (no Ig/C3
Diffuse proliferative glomerulonephritis LM“wire looping” of capillaries.
Diffuse proliferative glomerulonephritis (SLE) EMsubendothelial and sometimes intramembranous IgG-based ICs often with C3 deposition.
Diffuse proliferative glomerulonephritis IFgranular.
IgA nephropathy (Berger disease) LM.mesangial proliferation
IgA nephropathy (Berger disease) EMmesangial IC deposits.
IgA nephropathy (Berger disease) IFIgA-based IC deposits in mesangium.Renal pathology of Henoch-Schönlein purpura
Alport syndromeMutation in type IV collagen Ž thinning and splitting of glomerular basement membrane. Most commonly X-linked dominant.
Membranoproliferative glomerulonephritis (MPGN) Type Isubendothelial immune complex (IC) deposits with granular IF; “tram-track” appearance on PAS stain D and H&E stain E due to GBM splitting caused by mesangial ingrowth.
Membranoproliferative glomerulonephritis (MPGN) Type I Cause may be 2° to hepatitis B or C infection. May also be idiopathic
Membranoproliferative glomerulonephritis (MPGN) Type II (it is called?)also called dense deposit disease
Membranoproliferative glomerulonephritis (MPGN) Type II Causeis associated with C3 nephritic factor (stabilizes C3 convertase increasing  serum C3 levels).

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