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GIT pancreas- pathology

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drnieves's version from 2017-06-12 15:55

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Question Answer
Chronic pancreatitisChronic inflammation, atrophy, and calcification of the pancreas. Can lead to pancreatic insufficiency.
Chronic pancreatitis causesAlcohol abuse, CFTR mutations.
Amylase and lipase may or not may be elevatedChronic pancreatitis
Anemia + pancreatitisMC thymidine deficiency
Acute pancreatitisAutosuggestion of pancreas. Epigastric pain radiating to back, anorexia, nausea. Increase amylase and lipase.
Causes of acute pancreatitisGallstones, alcohol,trauma, steroids, mumps, autoimmune, scorpion sting, hypercalcemia/ hypertryglyceridemia, ERCP, sulfa drugs, NRTI, protease inhibitors,.
DIC, ARDS, diffuse fat necrosis, hypocalcemia, pseudocyst formation, hemorrhage, infarction, sepsis.Acute pancreatitis complications
Pancreatic adenocarcinomaFrom pancreatic ducts. ~1 yr survival. More common in head leading to obstructive jaundice.
Ass with CA 19-9 markerPancreatic adenocarcinoma
Risk factors for pancreatic adenocarcinomaSmoking, chronic pancreatitis, diabetes, >50 jewish/ african american.
Pancreatic adenocarcinoma sxAbdominal pain radiating to back, weight loss, migratory hrombophlebitis (Trousseau syndrome), courvoisier sign
Courvoisier signObstructive jaundice with non tender palpable gallbladder.
Whipple procedure, chemo, radiationPancreatic adenocarcinoma tx
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