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GI drugs

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oeshnoeugo123's version from 2018-03-26 03:01

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Question Answer
1. Al (Mylanta)
2. Mg (Maalox)
-both of these bother diazepam ABSORPTION
Can alter absorption of diazepam
1. omeprazole (prilosec); a PPI
2. cimetidine (Tagamet); an antihistamine (H2 receptor antagonist)
Can alter metabolism of diazepam and triazolam via 3A4 inhibition
Antacids
1. NaHCO3
2. CaCO3
3. Aluminum Hydroxide
4. Mg
Antacid used to neutralize gastric acids
cimetidine (Tagamet)
-H2 receptor antagonist
-antihistamine
generalized inhibitor of drug metabolism
Scopolamine
-antiemetic
-anticholinergic
Anticholinergic drug used to reduce seasickness
1. cimetidine
2. ranitidine
H2 receptor antagonist – decreases gastric acid secretion
1. Al (Mylanta)
2. Mg (Maalox)
3. CaCO3
4. NaHCO3
5. Sucralfate
May inhibit GI absorption of tetracycline
SucralfateMucosal protective agent
PPIs
1. omeprazole (Prilosec) - OTC
2. Lansoprazole (Prevacid) - OTC
3. esomeprazole (Nexium)
can cause esophageal candidiasis, mucosal atrophy of tongue, dry mouth, and increase risk of fractures, as well as pseudomembranous colitis
1. Loperamide (Immodium)
2. diphenoxylate (Lomotil)
Peripherally acting opioids used for diarrhea
PPIs
1. omeprazole (Prilosec) - OTC
2. Lansoprazole (Prevacid) - OTC
3. esomeprazole (Nexium)
Proton pump inhibitors (PPIs)
OdansetronSelective 5-HT3 receptor blocker used to reduce chemotherapy nausea and vomiting
Metoclopramide
-prokinetic drug; for heartburn
Stimulates GI tract motility – may cause Parkinson like symptoms
Misoprostil (Cytotec)synthetic analog of prostaglandin PGE-1 that stimulates mucous secretion and decreases gastric acid secretion
omeprazole (Prilosec)
-bothers dizepam METABOLISM
PPI that inhibits 3A4
memorize

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