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GERD

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wuriluxi's version from 2017-11-12 20:29

Section 1

Question Answer
Drugs that worsen GERD d/t a decrease in lower esophageal sphincter pressurenitrates, theophylline, calcium channel blockers, benzodiazepines
H2 receptor blockers interfere with absorption ofketoconazole, ampicillin, iron, digoxin
PPIs increase the action of what drugsbenzodiazepines, phenytoin, clarithromycin
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Section 2

Question Answer
GERD treatment mild. intermittent symptomsantacids, histamine 2 blockers
GERD treatment moderate symptomsprescription strength histamine 2 blocker or OTC PPI for 8-12 weeks
GERD treatment severe symptoms or erosive diseasePPI for 8-12 weeks
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Section 3

Question Answer
The higher the acid neutralizing capacity (ANC) the more effective an antacid isTrue
Sodium bicarbonate and calcium carbonate have the lowest ANCFalse
Antacids can decrease the absorption of other drugsTrue
antacids, anticholinergics, metoclopramide increase the effect of H2 receptor blockersFalse
omeprazole has a greater interaction with CYP450 drugs versus other PPIsTrue
memorize

Section 4

Question Answer
Adverse effects of antacidshypermagnesiemia, hypophosphatemia, acid rebound, hypercalcemia, osteomalacia
Signs of milk-alkali syndromeheadache, nausea, irritability, weakness
Adverse effects of histamine 2 blockersdiarrhea, arthralgias, rash, thrombocytopenia, confusion, confusion, dizziness, MSK pain, tachycardia
Adverse effects of PPIheadache, diarrhea, tachycardia, constipation, htn, insomnia, dizziness, peripheral edema
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Section 5

Question Answer
Examples of antacidscalcium carbonate, sodium bicarbonate, aluminum hydroxide, magnesium hydroxide
Examples of H2 receptor blockerscimetidine (tagamet), ranitidine (zantac), nizatidine (axid), famotidine (pepcid)
Examples of PPIomeprazole (prilosec), lansoprazole (prevacid), rabeprazole, esomeprazole (nexium), pantoprazole (protonix)
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Section 6

Question Answer
H2 receptor blockersreversible inhibition of acid secretory pump
Proton pump inhibitorsirreversible inhibition of acid secretory pump
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