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GERD Medications

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alchemist04's version from 2018-06-15 06:18

Histamine-2/H2 Blocker (Acid Reducer)

BrandGeneric
FamotidinePeptide (FP)
CimetidineTagamet (HB200) (CT)
RanitidineZantac (RZ)
NizatidineAxid (NA)
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Question Answer
H2 Blocker MOABlock the release of H2
When to take H2Take it 30 mins before meal OR QHS to suppress nighttime/bedtime production of acid
Side effects of H2Headache, abdominal pain, diarrhea, nausea, gas, sore throat, runny nose, and dizziness
H2 Blockers are not good forEsophagitis
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Proton Pump Inhibitors (PPIs) (Acid Reducer)

BrandGeneric
RabeprazoleAciphex (RA)
EsomeprazoleNexium (EN)
LansoprazolePrevacid (LP)
OmeprazolePrilosec, Zegerid (OPZ)
PantoprazoleProtonix (PP)
DexlansoprazoleDexilant (DD)
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Question Answer
PPI MOAPPI blocks the gastric H/K-ATPase, inhibiting gastric acid secretion. This effect enables healing of peptic ulcers, gastroesophageal reflux disease (GERD),
When to take PPIbest taken 1 hour (60 minutes) before meal
Side effects of PPIHeadache, diarrhea, abdominal pain, bloating, constipation, nausea and gas
PPI is good for1) protecting the esophagus from acid so that esophageal inflammation can heal 2) Healing for peptic ulcer
Interesting facts about PPIsPPIs are acid-activated prodrugs that convert to sulfenic acids or sulfenamides that react covalently with one or more cysteines accessible from the luminal surface of the ATPase.
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Promotility Agent

BrandGeneric
MetoclopramideReglan (MR)
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Question Answer
Promotility Agent MOAit stimulates the muscles of the gastrointestinal tract, which may prevent acids from staying in the stomach too long, and strenghthening the lower esophageal sphincter, reducing reflux into the esophagus
Side effect of Metoclopramide (Reglan)Drowsiness, fatique, diarrhea, restlessness and mvmt problems
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