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Genomics, Protemics and Metabolomics

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kmartin282's version from 2016-11-16 21:52

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Question Answer
Single nucleotide polymorphisms are used for what items?Genetic mapping, disease prediction and human identification
Name the following items in increasing complexity: genome, metabolome, transcriptome, proteomeThe following are shown in increased complexity: Genome, transcriptome, proteome, and metabolome.
What is genomics?Genomics is genome analysis; It predicts probability without determining whether or when this probability will ever manifest.
What gives a dynamic picture of the current status of an organism?Transcriptome, proteome and metabolome
What leads to the increasing levels of complexity seen in genes as you move from the genome to the metabolome?The increasing levels of complexity are caused by the combined interaction of genes, allowing multiple proteins to come from the same gene due to alternative splicing and gene promoters.
What chromosome is observed in chronic myelogenous leukemia?Philadelphia chromosome
Trisomy 21 is the cause of?Down Syndrome
What type of test looks for extra, duplicated or missing chromosomal segments?Chromosomal microarray analysis (CMA)
What is not a part of the gold standard for mutation detection?Fluorescence in situ hybridization (FISH)
What type of stain is utilized to reveal the banding pattern of each chromosome?Giemsa
What does Mass Spectrophotometry measure/determine? Molecular Mass of molecules
What are microarrays covered with to determine RNA transcripts?Oligonucleotides
How is Proteomics measurement carried out? Liquid chromatography plus Mass spectrometry
How does liquid chromatography separate proteins in proteomics testing? By charge/hydrophobicity
What does Comparative Proteomics help determine?Phenotypic differences in diseased vs. healthy organs
What does MALDI-TOF stand for?Matrix Assisted Laser Desorption/Ionization-TOF
What is TOF?time of flight mass spectrometry
What are some examples of metabolites?Sugars, amino acids, lipids, and nucleotides in a biological sample
Blood glucose, prostate-specific antigen, and BRCA ½ genes are ____. Biomarkers
Data are not _________ and _________ is not _________. information, information, knowledge
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