FYI perio

robbypowell's version from 2015-12-11 02:33


Question Answer
A 38 year old woman with tachycardia, heat intolerance, exophthalmia, excessive sweating, and a diffuse neck massGrave’s disease
Following are autoimmune disease except: Grave, Hashimoto, Cushing, Myasthenia gravisCushing
Which type of hypersensitivity is mediated primarily by Th1 CD4+ effector cellsType IV
Central T lymphocyte tolerance occurs inthe thymus (or thymal equivalent)
Systemic lupus erythematosus is an example of what type of autoimmune diseaseSystemic
A surface glycoprotein which is related to CD28 but, when bound to B7-1/B7-2 has the opposite effect as CD28 isCTLA-4 (peripheral tolerance induction)
All of the following are immunological components of type I hypersensitivity except which one: IgE, Mast cells, Eosinophils, Vasoactive mediators, TH1 effector T cellsTh1 effector cells
If an antigen presenting cells presents an antigenic peptide to a mature, naïve, functional T lymphocyte that neither expresses nor releases any T cell costimulators, the responding T cell becomes ___Anergic (enters a state of anergy)
Individuals who have myasthenia gravis may, rather frequently also haveThymoma
The autocrine expression and interaction of Fas and Fas-L, leading to the apoptosis of T lymphocytes is a manifestation ofPeripheral tolerance induction
Is Antibody-dependent cell cytotoxicity a manifestation of Type III hypersensitivity?NO (type 4)
A key finding in the laboratory diagnosis of systemic lupus erythematosus is antibody specific fords DNA
NK cells would most likely be involved in which type of hypersensitiviesType II
From a genetic standpoint, predisposition to autoimmune disease appears to be associated withA. Expression of certain HLA alleles & B. polygenic factors
Immunoglobulin specific for which surface receptors is commonly found in myasthenia gravisAch receptors
T lymphocytes are rendered tolerant byselection in thymus
Bacteria has been implicated in the development of which of these diseases of the stomach: peptic ulcer disease, MALT lymphoma, AdenocarcinomaALL OF THE ABOVE
T/F: Patients with a high prevalence of colonic adenomas have a high prevalence of colonic adenocarcinomaTrue
T/F: Barrett’s esophagus is a premalignant condition in the esophagusTrue
T/F: Barrett's esophagus has no association with esophageal SCCTrue
T/F: All Chronic acid reflux patients develop Barrett's esophagusFalse (most don't) (only some do)
T/F: Chronic H pylori infection is implicated in the development Esophageal adenocarcinomaFalse (barrett's is only risk factor for Esophageal Adenocarcinoma)
Barrett’s esophagus is an example of ___Metaplasia
A 2months old baby girl presents with jaundice. Ultrasound examination cannot identify a gallbladder or common duct. Liver biopsy shows fibrosis and inflammation of portal triads with florid bile ductular proliferation. The most likely diagnosis is Extrahpetic biliary ____Extrahepatic biliary atresia
In HIV infected patients, hairy leukoplakia is caused by epithelial infection by which virus?EBV
Which of the following metastatic patterns is the most common in gastrointestinal malignanciesliver
T/F: Most patients with Adenocarcinoma present with small sized malignancies because there are considerable early clinical symptomsFalse
which is clinicopathologic feature common to both Ulcerative Colitis and Crohn’s: Mucosal inflammation, Granulomas, fistulas, stomach diseaseMucosal inflammation
Example of secretory diarrhea isPatient with cholera
Tropheryma whippleii causes what multiorgan disease?Whipple disease
Which mutation is associated with development of dysplastic colonic polypsAPC suppressor gene mutation
T/F: Ulcerative Colitis is a malabsorption diseaseFalse (because colon does not absorb nutrients)
A 68 YO Japanese immigrant presented with abdominal pain and obstruction. At the time of endoscopy, a mass was found in stomach. Intestinal juices obtained during the endoscopy grew a microorganism that demonstrated urease activityGastric Adenocarcinoma
an 18-YO that was found to have ileitis at the time of exploration for suspected appendicitis. Chronic abdominal pain and diarrhea persisted, and a diagnosis of inflammatory bowel disease has been made. HE has recently developed and enterocutaneous fistulaCrohns disease
A 56 yo male has chronic abdominal pain and diarrhea. Small bowel biopsy demonstrates replacement of the lamina propria with foamy macrophages that stain positive for periodic aced-Schiff (PAS)Whipple Disease
Pictured is an iron stain positively of a liver biopsy on a 56 year ol aymptomatic male. He was found to have homozygous C282Y mutation of the HFE gene. Best treatmentheavy metal chelators and regular phlebotomy (Primary Hemochromatosis)
A 46 yo male presents with jaundice and right upper quadreant pain. Family members state that over the last several years his behavior has changed. On exam he has a large tender liver. Blood test show a low serum ceruloplasmin and a urine sample shows elevated copperWilson’s disease
patient with ____ failure develop a bleeding diathesis as a result of impaired clotting factor synthesisHepatic (liver manufactures clotting factors)
portal hypertension in _____ results from a combination of resistance to portal flow at the level of sinusoids and central veins, as well as from the formation of vascular anastomoses between hepatic artery branches and portal vein branches within the pathologic fibrous bands of cirrhosis hypertension
Select the single best statement about alchoholic liver disease: death from end stage alcoholic ingestion may be from gastrointestinal hemorrhage, infections or hepatocellular carcinoma. Cirrhosis
42. 58 yo man a liver biopsy that shows extensive parenchymal steatosis associated with acute inflammation, hepatocytes with eosinophilic cytoplasmic inclusions and bridging fibrosis. The most likely diagnosis isAlcoholic cirrhosis
Multifocal hepatocellular carcinoma is typically associate with what virusChronic Hepatitis B
A 35 yr old man was accidentally hit on his left leg in the region of his thigh by falling pallet rack. The skin was not broken as a result. Within 48 hours there was a 6X8 cm purple color to the site if injury. Which of the following substances has most likely accumulated at the site if injury to produce a yellow-brown color 15 days after injury?Hemosiderin
The cells that predominate in allergy and anaphalaxyis areeosinophil granulocytes and mast cells
The leukocyte responsible for cell-mediated immunity in TB isT lymphocyte


Infectious diseases may lead to a breakdown in tolerance to self peptides by:
a.molecular mimicry,
b.inducing an inflammatory response which in turn sstimulates APCs displaying self peptides to also express appropriate costimulators
(ANS: A&B)