Fungi and the Lung

benryan95's version from 2016-01-12 15:25


Question Answer
What are the 5 ways in which the fungi aspergillus affects the lung?Asthma, Allergic Bronchopulmonary Aspergillosis, Aspergilloma, Invasive Aspergillosis, Extrinsic allergic alveolitis
Which hypersensitivity reaction occurs in response to fungal spores in asthma?Type 1 Hypersensitivity reaction
In which groups does allergic bronchopulmonary aspergillosis tend to affect?Cystic fibrosis (2-25%) and asthma (1%)
What are the symptoms of allergic bronchopulmonary aspergillosis?Wheeze, cough, sputum, dyspnoea, recurrent pneumonia
How is allergic bronchopulmonary aspergillosis treated?Prednisolone for acute attacks
What is meant by a aspergilloma?A fungus ball within a pre-existing cavity (often caused by TB or sarcoidosis)
What are 5 possible presentations of aspergilloma?Asymptomatic, cough, haemoptysis, lethargy, weight loss
What are risk factors for invasive aspergillosis?immunocompromise, SLE, broad-spectrum antibiotic therapy
What is the % mortality for invasive aspergillosis?30%
What may extrinsic allergic alveolitis be caused by?Sensitivity to Aspergillus clavatus
What are the 3 typical complications of aspergilloma within pre-existing cavity?Infection, infarction, malignancy
What are the 3 typical complications of progression of allergic bronchopulmonary aspergillosis?Bronchiectasis, mucoid impaction and lobar collapse, upper lobe fibrosis

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