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Formulation (excipients)

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fatima101's version from 2017-04-13 13:48

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Requirements for diluentsinert -not to cause pharmacological or chemical activity of its own biocompatible with drug substance and other excipient used in the formulation,non-hygroscopic-formulation does not absorb significant amounts of moisture from its surroundings, good dilution capacity, compactable and similar size to active ingredient, non conducive to microbiological development, non toxic , cheap , have no effect on bioavailability of drugs
Examples of diluentslactose, microcystalline cellulose, starch, dextrose, mannitol, sorbitol, maltodextrin, sucrose , dicalcium and tricalcium phosphate
Examples of wet bindersHPMC HPC Pre-gelatanised strach PVP Tradgacanth Acacia Pectin
Examples of lubricantsMagnesium stearate, Stearic acid, PEG, Hydrogenated vegetable oils
Purpose of glidantImprove flow of powders or granules
Examples of glidantTalc colloidal silica (Aerosil)
Purpose of antiadherentsPrevent powders or granules from sticking to the punch faces.
Example of antiadherentsTalc and starch
Examples of disintegrantsModified starch starch clrosslinked PVP Microcrystalline cellulose
How do we choose excipientsFunction , stability
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