First Aid - Psychiatry (Part 2)

arold001's version from 2015-12-27 00:56

Section 1

Question Answer
Whats the MOA of methylphenidate, amphetamines?increases NE and DA in synaptic cleft
whats the MOA of TYPICAL antipsychotics?D2 receptor antagonist --> increase cAMP
what are 2 MAJOR side effects of typical antipsychoticsneuroleptic malignant syndrome and tardive dyskinesia
whats the tx for NMS?dantrolene and bromocriptine
what are the 5 typical antipsychoticsHigh potency: trifluoperazine, fluphenazine, haloperidol (Try to Fly High).
Low potency: Chlorpromazine, Thioridazine (cheating thieves are low)
whats the main side effect in high potency vs. low potency typical antipsychoticsHigh potency antipsychotics: EPS
Low potency antipsychotics: HAM side effects
whats the MOA of atypical antipsychotics?5-HT2, DA, alpha, H1 receptors
which 2 atypical antipsychotics causes most weight gain?olanzapine and clozapine
what are the 2 feared side effects of clozapine?agranulocytosis (need weekly CBC) and SEIZURES
which atypical antipsychotic is a/w QT prolongation?ziprasidone and thioridazine
what are the side effects of lithium (LMNOP)lithium - Movement (tremor), Nephrogenic diabetes insipidus (ADH antagonist), hypOthyroidism, Pregnancy problems (ebsteins anomaly)
whats the MOA of buspirone in tx of GAD?buspirone = 5-HT1A partial receptor agonist
why is buspirone a good drug to tx GAD?it does NOT cause sedation, addiction or tolerance
whats the MOA of sertraline?SSRI
whats the MOA of citalopram?SSRI
what sexual side effects does SSRI cause?anorgasmia and DECREASED LIBIDO
how long does it take for antidepressants to have an effect?4-8 weeks or 1-2 months

Section 2

Question Answer
whats the tx for serotonin syndrome?cyproheptadine = 5-HT2 receptor antagonist
what is serotonin syndrome?fever, HTN, myoclonus, CV collapse, diarrhea, seizures
whats the MOA of SNRI?inhibits serotonin and NE reuptake
what 2 disorders does venlafaxine tx?GAD and panic disorders
what SNRI is used to tx diabetic peripheral neuropathy?duloxetine...has greater effect on NE
whats the most common side effect of SNRI?increased BP
what type of drug is doxepin and amoxapine?TCA
whats the MOA of TCA?inhibits reuptake of serotonin and NE
whats the MOA of TCA and SNRI?inhibits reuptake of serotonin and NE
which TCA is used to tx enuresis?imipramine
what are the 3 C's of TCA?convulsions, coma, cardiotoxicity (arrhythmias)
name the 4 MAOITranylcypromine, Phenelzine, Isocarboxazid, Selegiline (Takes Pride In Shanghai)
whats the MOA of MAOI?increases NE, serotonin, DA
what major side effect is a/w MAOI?hypertensive crisis
what are 3 OTC contradictions with MAOI?st. johns wort, merperidine, dextromethophan, pseudoephedrine
whats the MOA of bupropion?increase NE and DA
name 4 atypical antidepressantsbupropion, mirtazepine, maprotiline, trazadone
why would bupropion be favored over SSRI?BUPROPION = NO sexual side effects
whats the MOA of mirtazapine?alpha2-antagonist (increases NE and serotonin) and 5-HT3 receptor antagonist
which atypical antidepressant should you use in depressed elderly pts with insomnia?mirtazapine = increase appetite, weight gain and sedation
whats the MOA of maprotiline?NE reuptake inhibitor
whats the MOA of trazadone (mainly for insomnia)?inhibits serotonin reuptake

Section 3

Question Answer
tx for alcohol withdrawalbenzo
3 tx options for anxietySSRI, SNRI, buspirone
2 tx options for bipolar disordermood stabilizers (lithium, valproate, carbamazepine), atypical antipsychotics
tx for bulimia?SSRI (fluoxetine)
tx for depression with insomniamirtazapine or trazadone
2 tx for OCDSSRI or clomipramine
3 tx for panic disorderSSRI, venlafaxine, benzos
tx for PTSD and social phobiaSSRI

Section 4

Question Answer
Which cluster: odd or eccentric; inability to develop meaningful relationships. No psychosis; genetic a/w schizophreniacluster A personality disorders = odd and eccentric
which cluster: dramatic, emotional, erratic; genetic a/w mood disorders and substance abusecluster B = dramatic, emotional, erratic
which cluster: anxious or fearful; genetic a/w anxiety disorderscluster C = anxious or fearful
what are the 3 cluster A personality disorders?1) paranoid 2) schizoid 3) schizotypal
what are the 4 cluster B personality disorders?1) antisocial 2) borderline 3) histrionic 4) narcissistic
what are the 3 cluster C personality disorders?1) avoidant
2) obsessive compulsive
3) dependent
which personality disorder: voluntary social withdrawal, limited emotional expression, content with social isolationschizoid
which personality disorder: eccentric appearance, odd beliefs, magical thinking, interpersonal awkwardnessschizotypal
which personality disorder: excessive emotionality and excitability, attention seeking, sexually provocative, overly concerned with appearancehistrionic

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