First Aid - Important Cytokinesrename
gohuxiku's version from 2016-10-21 03:29
Mnemonic of Important Cytokines (Hot T-Bone stEAk)
|Hot||IL-1 causes fever (hot)|
|T-||IL-2 stimulates T-cells|
|Bone||IL-3 stimulates Bone marrow|
|stEak||IL-4 stimulates IgE production|
|steAk||IL-5 stimulates IgA production|
|Cytokines||Secreted by||Targets and Major Effects|
|IL-1||Macrophages, B-cells, monocytes, osteoblasts||Target(s): Endothelium |
Effects: Fever (endogenous pyrogen), acute Inflammation, Increased Vascular Permeability by activating endothelium to express adhesion molecules; induces chemokine secretion to recruit leukocytes, induces B-cells to multiply, activates osteoclasts(bone resorption).
|IL-6||Macrophages; TH2 Cells||Target(s): T-Cell, B-Cell |
Effects: Endogenous pyrogen. Causes fever and stimulates production of acute phase proteins.
|IL-8||Macrophages||Target(s): Neutrophil |
Effects: Major chemotactic factor ("Clean up on aisle 8." Neutrophils are recruited by ___to clear infections)
|IL-12||Macrophages||Target(s): TH1, NK Cell |
Effects: Induces T cell differentiation into TH1 cells which in turn secrete IFN which activates macrophages causing feedback loop that contributes to dvlp of granulomatous inflammation. Activates NK cells. Also secreted by B cells.
|TNF-α (cachectin)||Macrophages||Target(s): Endothelium |
Effects: Mediates septic shock. Causes leukocyte recruitment, vascular leak.
|IL-2||ALL T-Cells||Target(s): T-Cell, B-Cell, NK Cell |
Effects: Stimulates growth of helper, cytotoxic and regulatory T-Cells.
|IL-3||activated T cells, mast cells, NK, Eosinohils||Target(s): Stem Cells |
Effects: Supports growth and differentiation of bone marrow stem cells.stimulates growth of mast cells. promotes histamine release. Functions like GM-CSF.
|TH1 Cells, Tc, DC, NK||Target(s): Macrophage, TH1 cells , NK, |
Effects: Activates macrophages, NK, and TH1 cells. Supresses TH2 cells. Has antiviral and antitumor properties (increases MHC I and II expression and antigen presentation in all cells), inhibits IL-4-dependent IgE synth
|IL4||TH2 Cells, macrophages, mast cells||Target(s): T-Cell, B-Cell |
Effects: Induces differentiation in TH2 cells. Promotes growth of B cells. Enhances class switching to IgE and IgG., inhibits Th1 and promote Th2 prolif, activates M2 macrophages
|IL5||TH2 Cells, mast, Eosinophils||Target(s): B-Cell, Eosinophils |
Effects: Promotes B-cell class switching from IgM to IgA. Stimulates growth and differentation of eosinophils.
|IL10||TH2 Cells, mast , macrophage, Treg||Target(s): TH1 |
Effects: Down-regulates the expression of TH1 cytokines, MHC class II antigens, and costimulatory molecules.attenuate inflammation
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