First Aid - Immuno

shaile's version from 2015-06-06 17:50

important cytokines & cell markers

HOT, TBone stEAK
Question Answer
IL-1pyrogen, activates endothelium adhesion molecules, recruits leukocytes; from macrophages
IL-2stimulates T cells; from all T-cells
IL-3stimulates bone marrow stem cells; from all T cells
IL-4IgE class switching & IgG, induces Th2 differentiation; from Th2 cells
IL-5IgA class, and Eosinophils; from Th2 cells
IL-6pyrogen; from macrophages and Th2 cells
IL-8PMN chemotactic (IL-8, C5a, LTB4) factor; from macrophages
IL-10modulates inflammatory response (similar to TGF-b), inhibits Th1 and activates Th2; from Th2 cells
IL-12induces Th1 differentiation, activates NK cells; from macrophages
TNF-amediates septic shock, from macrophages
IFN-yactivates macrophages and Th1 cells + MHC II, suppresses Th2 cells, has antiviral and antitumor properties; from Th1 cells
Th1 cellsIL-2, INF-gamma
Th2 cellsIL-4, IL-5, IL-10
Th1 cells --> Activates macrophagesINF-gamma
Fever (acute phase reactants)IL-1, IL-6, TNF-alpha
IFN-alpha, IFN-betainterferes w/ viral protein synthesis (kills bacteria) + ↑ MHC I (CD8+ T-cells)
CachexiaTNF-alpha (from macrophages - septic shock, activates endothelium), IFN-gamma (activates macrophages), IL-6 (fever)

CD Markers

Question Answer
CD 3all T-cells-- associated with TCR for signal transduction (TCR-C3 complex)
CD 5Mantle Cell Lymphoma (Non-Hodgkin's Lymphoma)
CD 4Helper T-cells--also have CD40 ligand, Tregs (also CD 25)
CD 8Cytotoxic T-cells
CD 13 & CD 33M0-M6 AML (Acute Myeloid Leukemia)
CD 14Macrophages--- binds Lipid A on Gram (-) LPS--> initiating septic shock
CD 15 & CD 30Reed-Sternberg Cells (Hodgkin's Lymphoma)
CD 16 & 56Natural killer cells
CD 18Leukocyte Adhesion deficiency
CD 19, CD 20, CD 21B-cells
CD 21B-cells + receptor for EBV
CD 28on T-cells, binds w/ B7 on APC (second signal)
CD 34Hematopoietic Stem Cells
CD 41 & 61M7 AML (Acute Myeloid Leukemia)
CD 55/59stops complement C9 binding, DAF (GPI anchored enzyme) = deficiency --> Paroxysmal Nocturnal Hemoglobinuria
CD 95Fas-Fas ligand, extrinsic apoptosis


Question Answer
Antinuclear antibodies (ANA)SLE, nonspecific
AntihistoneDrug-induced lupus
Anti-IgG (Rheumatoid Factor) Anti-CCPRheumatoid arthritis (Rheumatoid Factor)--- anti IgG less specific, Anti-CCP specific
AnticentromereScleroderma (CREST syndrome) = LOCALIZED-- Calcinosis, Raynaud phenomenon, Esophageal dysmotility, Sclerodactyly, and Telangiectasia
Anti-DNA topoisomerase IScleroderma (diffuse) (Anti-Scl-70) = SYSTEMIC
Anti-mitochondrial1* biliary cirrhosis
Anti-platelet Abs (IgG against Gp 2b/3a)idiopathic thrombocytopenic purpura (ITP)
Anti-gliadin, IgA anti-endomysial, IgA anti-tissue transglutaminaseCeliac disease
Anti-basement membraneGoodpasture's syndrome
Anti-desmoglein (anti-epithelial)Pemphigus vulgaris-- Desmosome (macula adherens)—structural support via keratin interactions.
Anti-hemidesmosome (anti-epithelial)Bullous Pemphigoid (pemphus-like)-- Hemidesmosome—connects keratin in basal cells to underlying basement membrane
Anti-microsomal (anti-peroxidase)Hashimoto's thyroiditis
Anti-thyroglobulinHashimoto's thyroiditis
Anti-Jo-1Polymyositis, dermatomyositis (Anti-SPR, Anti-Mi-2)
Anti-SS-A (anti-Ro)Sjogren's syndrome
Anti-SS-B (anti-La)Sjogren's syndrome
Anti-U1 RNP (ribonucleoprotein)Mixed connective tissue disease
Anti-smooth muscleAutoimmune hepatitis
Anti-glutamate decarboxylaseType 1 diabetes mellitus
Anti-parietal cellPernicious Anemia
c-ANCA (anti-neutrophil antibodies)Wegener's granulomatosis
p-ANCA (anti-neutrophil antibodies)Microscopic Polyngiitis, Churg-Strauss Syndrome
Ant-TSH Receptor AntibodiesGrave's Disease
Anti-cardiac muscle antibodyDressler's syndrome and post MI syndrome