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First Aid - Immuno

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mlinnie's version from 2018-11-09 22:50

important cytokines

Question Answer
IL-1pyrogen, activates endothelium adhesion molecules, recruits leukocytes; from macrophages
IL-2stimulates T cells; from Th1 cells
IL-3stimulates bone marrow stem cells; from all T cells
IL-4IgE class switching, induces Th2 differentiation; from Th2 cells
IL-5IgA class; from Th2 cells
IL-6pyrogen; from macrophages and Th cells
IL-8PMN chemotactic factor; from macrophages
IL-10modulates inflammatory response (similar to TGF-b), inhibits Th1 and activates Th2; from Th2 cells
IL-12induces Th1 differentiation, activates NK cells; from macrophages
TNF-amediates septic shock
IFN-yactivates macrophages and Th1 cells, suppresses Th2 cells, has antiviral and antitumor properties; from Th1 cells
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autoantibodies

Question Answer
Antinuclear antibodies (ANA)SLE, nonspecific
Anti-dsDNA, anti-SMITHSLE
AntihistoneDrug-induced lupus
Anti-IgG (rheumatoid factor)Rheumatoid arthritis
AnticentromereScleroderma (CREST)
Anti-Scl-70 (anti-DNA topoisomerase I)Scleroderma (diffuse)
Antimitochondrial1* biliary cirrhosis
Antigliadin, antiendomysialCeliac disease
Anti-basement membraneGoodpasture's syndrome
Anti-desmogleinPemphigus vulgaris
Antimicrosomal, antithyroglobulinHashimoto's thyroiditis
Anti-Jo-1Polymyositis, dermatomyositis
Anti-SS-A (anti-Ro)Sjogren's syndrome
Anti-SS-B (anti-La)Sjogren's syndrome
Anti-U1 RNP (ribonucleoprotein)Mixed connective tissue disease
Anti-smooth muscleAutoimmune hepatitis
Anti-glutamate decarboxylaseType 1 diabetes mellitus
c-ANCAWegener's granulomatosis
p-ANCAother vasculitides
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