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First Aid - Hem-Onc

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mlinnie's version from 2018-11-09 22:51

heme synthesis enzyme pathology

Question Answer
ALA dehydrataselead poisoning
ferrochelataselead poisoning
porphobilinogen deaminase (uroporphyrinogen-I-synthase)acute intermittent porphyria
uroporphyrinogen decarboxylaseporphyria cutanea tarda
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chromosomal translocations

Question Answer
t(9;22)Philadelphia chr, CML (bcr-abl hybrid)
t(8;14)Burkitt's lymphoma (c-myc activation)
t(14;18)Follicular lymphoma (bcl-2 activation)
t(15;17)M3 type of AML (responsive to all-trans retinoic acid)
t(11;22)Ewing's sarcoma
t(11;14)Mantle cell lymphoma
t(12;21)better prognosis in ALL
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