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lunalovegood's version from 2016-10-10 01:48

Section 1

Question Answer
ANS - Symp - HeartNE
ANS - Symp - Smooth muscleNE
ANS - Symp - GlandsNE
ANS - Adrenal MedullaAch acts on adrenal medulla to produce NE & Epi
ANS - Symp - Sweat glands & some blood vesselsAch
ANS - ParaAch
Somatic Nervous SystemAch
memorize

Section 2

Question Answer
Is Ach more like Captain Jack Sparrow or Kimmy Schmidt?Captain Jack (stored in vesicles, waiting for the opportune exocytosis)
M1-M5Muscarinic receptors (Methacholine, Carbachol, Bethanechol, Muscarine, Pilocarpine)
Nn, NmNicotinic receptors (Nicotine)
Nmactivation at NeuroMuscularJxn (skeletal/voluntary muscle)
Nnactivation of SNS & PNS ganglionic sites
Muscarinic utilize ___ type receptorsG-protein coupled
Nicotinic utilize ___ type receptors Ion channel
Adrenergic utilize ___ type receptorsG-protein coupled
Salivation, Lacrimation, Urination, DefecationPNS
Miosis vs. Mydriasis constriction vs. dilation (Para vs. Symp)
Most ANTIcholinergics block the ____ receptor.muscarinic (i.e. Atropine)
Parasympathetic causes broncho_____ (constriction or dilation)bronchoconstriction
Cholinomimetics cause... bronchoconstriction, hypotension, SLUD, sweating, ____ & _____ulcers & cramps
Like pulpitis, Anticholinesterases can be ___ or ____.reversible or irreversible
Quartnery NH4+ vs. Organophosphates - which passes BBB?organophosphates
Atropine, BDZ, and Pralidoximetreat acute toxicity of organophosphates
memorize

 

Cholinomimetics
Question Answer
Choline esters cholinomimetic agonist
Natural alkaloidscholinomimetic agonist
Methacholinecholinomimetic agonist (choline ester)
Carbacholcholinomimetic agonist (choline ester)
Bethanecholcholinomimetic agonist (choline ester)
Muscarinecholinomimetic agonist (natural alkaloid - PASSES BBB)
Pilocarpinecholinomimetic agonist (natural alkaloid - PASSES BBB)
Nicotinecholinomimetic agonist (natural alkaloid - PASSES BBB)
The only nicotinic receptor activatornicotine (the rest activate muscarinic)
memorize

 

Anticholinesterases
Question Answer
Edrophoniumreversible
Neostigminereversible
Physiostigmine (eserine)reversible
Organophosphatesirreversible (pesticides/chemical warfare -- or -- ophthamology)
Parathionirreversible (organoP)
Isoflurophateirreversible (organoP)
Echothiophateirreversible (organoP)
Organophosphates interact with ___ site on AchE.esteratic
Neostigmine interacts with ___ site on AchE.both (*can interact directly as cholinomimetic*)
Physostigmine interacts with ___ site on AchEboth
Edrophonium interacts with ___ site on AchEcatalytic ???
Poisoning effect is from...effecting CNS
T/F - Treats glaucoma, myasthenia gravis & Alzheimer's.True
Antidote for atropinePhysostigmine (and BDZ)
Reverse neuromuscular blockadeNeostigmine
Senile Alzheimer'sTacrine
Xerostomiapilocarpine, neostigmine
Glaucomapilocarpine, carbachol, physostigmine + pilocarpine, echothiophate + isoflurophate
Myasthenia gravisedorphonium, neostigmine, pyridostigmine
memorize

 

Antimuscarinics (competitive antagonists)
Question Answer
Atropinenatural
Scopolaminenatural
Homatropinesemisynthetic
Methantheline, Probantheline, Ipratropiumsynthetic quaternary
Benztropine, Cyclopentolatesynthetic non-quaternary
Can't block _________ receptornicotinic
T/F - Mydriasis, cycloplegia, increase intraoccular pressure, prevent laryngospasm, xerostomia, inhibit GI, increase HR, increase urinary retention, increase body tempTrue
Sedationscopolamine
Motion sicknessscopolamine
Why do quaternary NH4 compounds have more peripheral effects?no BBB, thus no CNS, thus more peripheral ganglionic effect
T/F - CONTRAINDICATION FOR NARROW ANGLE GLAUCOMA.True
COPDIpratropium
T/F - Peptic ulcer benefits questionable.True
GITPirenzepine
T/F - Drug interactions with ANTIHISTAMINES, isoniazid, MAOI, tricyclic antidepressants, and phenothiazines.True
Good antisialogueglycopyrrolate (1-2mg 30-45m before procedure)
memorize

 

Nicotinic
Question Answer
Nicotinedepolarizing
Trimethaphan, TEAnon-depolarizing, competitive
Hexamethophoniumnon-depolarizing, non-competitive
Mecamylaminenon-depolarizing, non-competitive
Adverse effects?LOTS
Endotracheal intubationssuccinylcholine
memorize

 

Adrenergic
Question Answer
Direct agonist needs... catechol ring plus OH on Beta carbon
Indirect agonist needs...1 or no OH on ring and no OH on Beta carbon (less OH for BBB)
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