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emmurphy11's version from 2015-04-10 21:08

Receptors/signalling

Type

 

Question Answer
alpha 2 receptorsGi GPCR
alpha 1 receptorsGq GPCR
beta 1 receptorsGs GPCR
beta 2 receptorsGs GPCR
calcitonin receptorsGs AND Gq GPCR
histamine (H1) receptorGq GPCR - "qlassic" effects of histamine
histamine (H2) receptorGs GPCR - gastric acid secretion
vasopressin (V1) receptorsGq GPCR
vasopresson (V2) receptorsGs GPCR
somatostatin receptorsGs GPCR
epidermal growth factorintrinsic tyrosine kinase
estrogen receptorintracellular steroid hormone
insulin receptorintrinsic tyrosine kinase
rhodopsinGq GPCR
M1 receptor (mAChR)Gq GPCR
M2 receptor (mAChR)Gi GPCR
M3 receptor (mAChR)Gq GPCR
D1 (DA)Gs GPCR
D2 (DA)Gi GPCR
atrial natriuretic peptidecGMP (BNP, too)
nitric oxidecGMP
platelet-derived growth factor (PDGF)intrinsic tyrosine kinase
1,25-dihydroxycholecalciferolintracellular R
GABACl- channel
nicotinic AChRnon-selective cation channel (Ca2+, Na+, K+)
IGF-1intrinsic tyrosine kinase
FSHcAMP
LHcAMP
ACTHcAMP
TSHcAMP
CRHcAMP
hCGcAMP
MSHcAMP
PTHcAMP
calcitonincAMP
GHRHcAMP
glucagoncAMP
BNPcGMP (ANP, too)
GnRHIP3
oxytocinIP3
TRHIP3
angiotensin IIIP3
gastrinIP3
testosteroneintracellular
T3intracellular
T4intracellular
cortisolintracellular
aldosteroneintracellular
progesteroneintracellular
FGFintrinsic tyrosine kinase
prolactinreceptor-associated tyrosine kinase
cytokinesreceptor-associated tyrosine kinase
GHreceptor-associated tyrosine kinase
G-CSFreceptor-associated tyrosine kinase
erythropoietinreceptor-associated receptor kinase
thrombopoietinreceptor-associated receptor kinase
platelet activating factorGq
memorize

 

Question Answer
Gi-assoc receptor actions(-)AC = decreased cAMP, PKA
Gs-assoc receptor actions(+)AC = increased cAMP, PKA
Gq-assoc receptor actions(+)PLC = increased PKC, DAG, IP3
memorize

 

Question Answer
DNA-binding proteinsTFs, thyroid proteins, steroids, vit D receptors, retinoic acid receptors
transcription factor-myc
Calcium-binding proteinscalmodulin
G-protein-assocRAS (GTPase)
JAK/STAT-assocprolactin, cytokines, GH, G-CSF, erythropoietin, thrombopoietin
MAP kinase-associnsulin, IGF-1, FGF, PDGF, EGF (growth factors)
memorize

Functions

 

Question Answer
alpha 1vasoconstriction, pupil dilation (mydriasis), intestinal + bladder sphincter muscle contraction
alpha 2decreased sympathetic outflow = decreased insulin release, decreased lipolysis, increased plt aggregation, decreased aqueous humor production
beta 1increased HR, cardiac contractility, renin release, lipolysis
1 heart
beta 2vasodilation, bronchodilation, increased lipolysis, increased insulin release, decreased uterine tone, ciliary muscle relaxation (look into distance), increase aqueous humor production
2lungs, 2 eyes
M1CNS, enteric nervous system
M2decreased HR, atrial contractility
M3increased exocrine gland secretions, increased peristalsis, increased bladder contraction, bronchoconstriction, pupil constriction (miosis), ciliary muscle contraction (look at close object, accommodation)
3 major actions: digestion; peeing; seeing
D1relaxation of renal vascular SM, CNS
D2neuromodulatory
H1mucus production (nose, bronchi), increase vascular permeability, contraction of bronchioles, pruritis, pain
H2increase gastric acid secretion
V1vasoconstriction
V2increase H2O reabs in collecting tubules of kidney (increase aquaporin expression)
memorize