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Autoantibodies
| Question | Answer |
|---|
| Anti-nuclear antibodies (ANA) | SLE, nonspecific |
| Anti-dsDNA, anti-Smith | SLE |
| Antihistone | drug-induced SLE |
| Anti-IgG | Rheumatoid Arthritis (Rheumatoid factor ) |
| anti-cyclic citrullinated protein antibodies (anti-CCP) | Rheumatoid Arthritis |
| Anticentromere | Scleroderma (CREST) |
| Anti-Scl-70 (anti-DNA topoisomerase I) | Scleroderma (diffuse) |
| Antimitochondrial | 1˚ biliary cirrhosis |
| Anti-gliadin, Anti-endomysial | Celiac disease |
| Anti-basement membrane | Goodpasture's syndrome |
| Anti-desmoglein (Anti-desmosome) | Pemphigus Vulgaris |
| Anti-microsomal, anti-thyroglobulin | Hashimoto's thyroiditis |
| Anti-Jo-1 | Polymyositis, Dermatomyositis |
| Anti-SS-A (Anti-Ro) | Sjogren's Syndrome |
| Anti-SS-B (Anti-La) | Sjogren's Syndrome |
| Anti-U1 RNP (ribonucleoprotein) | Mixed connective tissue disease |
| Anti-smooth muscle | Autoimmune hepatitis |
| Anti-glutamate decarboxulase (Anti-glutamic acid) | Type 1 diabetes mellitus |
| c-ANCA | Wegener's granulomatosis |
| p-ANCA | Churg strauss, polyarteritis nodosa |
| Anti-gliadin | Celiac disease |
| Anti-endomysial | Celiac disease |
| Anti-dsDNA | SLE |
| Anti-Smith | SLE |
| Anti-platelet | Idiopathic thrombocytopenic purpura |
| Anti TSH receptor | Graves disease |
| Anti ACh receptor | Mysthenia Gravis |
| memorize |
Lymph Drainage (p222)
| Question | Answer |
|---|
| Upper limb | Axillary |
| Lateral breast | Axillary |
| Duodenum | Superior mesenteric |
| Jejunum | Superior mesenteric |
| Stomach | Celiac |
| Sigmoid colon | Colic -> inferior mesenteric |
| Rectum (above pectinate) | Internal iliac |
| Anal canal (below pectinate) | Superficial inguinal |
| Testes | Superior and deep plexuses -> para-aortic |
| Scrotum | Superficial inguinal |
| Thigh | Superficial inguinal |
| Lateral side of dorsum of foot | Popliteal |
| Which lymphatic duct: right arm and right half of head | Right lymphatic duct |
| Which lymphatic duct: everything else | Thoracic duct |
| memorize |
Immunosuppressants MOA
| Question | Answer |
|---|
| Cyclosporine MOA | binds cyclophilins - inhibit calcineurin - prevent IL-2/IL-2 receptor production |
| Tacrolimus MOA | binds FK-binding protein - inhibit IL-2 |
| SIrolimus MOA | binds FK-binding protein 12 inhibits mTOR(mammalian target of rapamycin) - prevents T-cell proliferation in response to IL-2 |
| Daclizumab MOA | Ab vs. IL-2R |
| Azathioprine (6-MP) MOA | interfere with metabolism/synth of nucleic acids (Toxic to proliferating lymphocytes) |
| Azathioprine (6-MP) Pearl | 6-MP is metabolized by xanthine oxidase and therefore toxic effects increased by concurrent use with allopurinol |
| Muromonab-CD3 (OKT3) MOA | Ab vs. CD3 on surface of T cells (blocks T-cell signal transduction) |
| memorize |
Immunosuppressants SE
| Question | Answer |
|---|
| Cyclosporine Toxicity | predispose to viral infections, nephrotoxic, gout |
| Tacrolimus Toxiticy | significant nephrotoxicity, peripheral neuro, HTN, pleural effusion, hyperglyc |
| SIrolimus toxicity | hyperlipidemia, thrombocytopenia, leukopenia |
| Azathioprine (6-MP) Toxicity | BM suppression, |
| Azathioprine (6-MP) Pearl | 6-MP is metabolized by xanthine oxidase and therefore toxic effects increased by concurrent use with allopurinol |
| Muromonab-CD3 toxicity | cytokine release syndrome, hypersensitivity reaction |
| memorize |
Immunosuppressants Uses
| Question | Answer |
|---|
| Cyclosporine Use | suppress organ rejection post transplant |
| Tacrolimus Use | Potent for organ transplant |
| SIrolimus use | kidney transplant, drug-eluting stents |
| Azathioprine (6-MP) Use | kidney transplant, autoimmune disorders |
| Muromonab-CD3 Use | post kidney transplant |
| memorize |
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