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Extra-vasation

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lailay's version from 2015-09-03 18:18

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Question Answer
What are the 4 steps of leukocyte extravasation?1) Marginatiion and rolling 2) Tight-binding 3) Diapedesis 4) migration
which proteins (4) on the vasculature/stroma facilitate Margination and rolling?P-selectin, E-selectin, (GlyCAM-1, CD34)
which proteins on the leukocytes (2) facilitate Margination and rolling?Sialyl-LewisX, Sialyl-LewisX, (L-selectin)
which proteins (2) on the vasculature/stroma facilitate tight binding?I-CAM-1 (CD54) & VCAM-1 (CD106)
which proteins on the leukocytes facilitate tight binding? (2)CD11/18 integrins (LFA-1, Mac-1) & VLA-4 integrin
which protein on the vasculature/stroma facilitate Diapedesis?PECAM-1 (CD31)
which protein on the leukocytes facilitate DiapedesisPECAM-1 (CD31)
which protein on the vasculature/stroma facilitate migration?Chemotactic products released in response to bacteria: C5a, LTB4, IL- 8,N-formylmethionine , kallikrein, platelet-activating factor (CLINK)
which protein on the leukocytes facilitate Migration?various
What is the definition Diapedesis?leukocyte travels between endothelial cells and exits blood vessel
What is migration?leukocyte travels through interstitium to site of injury or infection guided by chemotactic signals
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