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Exotoxins

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lilyo's version from 2016-06-02 12:52

Section

Question Answer
Corynebacterium diphtheriaeinactivates elongation factor 2 (inhibits protein synthesis)
Pseudomonas aeruginosainactivates elongation factor 2 (inhibits protein synthesis)
Shigellainactivate 60s ribosome by removing adenine from rRNA (inhibits protein synthesis)
EHECinactivate 60s ribosome by removing adenine from rRNA (inhibits protein synthesis)
ETECheat-labile - overactivate adenylate cyclase --> increase cAMP --> increase Cl- secretion in gut and H20 efflux, heat-stable - overactivate guanylate cyclase --> decreased resorption of NaCl and H20 in gut (increase fluid secretion)
Bacillus anthracismimics adenylate cyclase enzyme (increase fluid secretion)
Vibrio choleraoveractivates adenylate cyclase by permanently activating Gs --> increased Cl- secretion in gut and H20 efflux (increase fluid secretion)
Bordatella pertussisoveractivates adenylate cyclase by disabling Gi, impairing phagocytosis to permit survival of microbe (inhibits phagocytic ability)
C. tetaniprotease that cleaves SNARE, prevents release of inhibitory (GABA and glycine) neurotransmitters from Renshaw cells in spinal cord (inhibit release of NT)
C. botulinumprotease that cleaves SNARE, prevents release of stimulatory (ACh) signals at neuromuscular junctions --> 􏰂flaccid paralysis
C. perfringensPhospholipase (lecithinase) that degrades tissue and cell membranes
Strep pyogenes streptolysin OProtein that degrades cell membrane
Staph aureusTSST-1 - Binds to MHC II and TCR outside of antigen binding site to cause overwhelming release of IL-1, IL-2, IFN-γ, and TNF-α --> shock
Strep pyogenesBinds to MHC II and TCR outside of antigen binding site to cause overwhelming release of IL-1, IL-2, IFN-γ, and TNF-α --> shock
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