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Examples of Inherent Resistance

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roshanbagga's version from 2017-08-07 19:10

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Question Answer
Penicillin/Beta-Lactams are resisted by mycoplasma bac (lack cell wall, no PG or transpeptidases - B-lactams have nothing to target)
Aminoglycosides are resisted byanaerobes - oxidative phosphorylation blocked aminoglycosides doesn't occur in anaerobes
Glycopeptides e.g. Vancomycin are resisted bygram -ve bac - large antibiotics can't penetrate the outer membrane porins
Nitroimidazoles are resisted byAerobes - they lack the flavodoxin that activates nitroimidazoles
Biofilms are resistant against multiple ABs becausethere is lack of penetration due to EPS adhesive layer - reduced microbial metabolic activity
Sulfonamides/Trimethoprim (SMX/TMP) are resisted byenterococci, who lack folic acid synthesis pathway
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