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Exam 3

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hiwawaha's version from 2016-01-07 23:15

Amino Acids (general)

Question Answer
Nonessential AAsGlutamate, Serine, Aspartate, Asparagine, Alanine (SEDAN)
Conditionally Essential AAsGlutamine, Proline, Arginine, Glycine, Cysteine, Tyrosine (QPRGCY)
GlucogenicDARN EQ CHIMPS TWYVF
KetogenicLYFKWIT (LK only pure ketogenic)
BothFWITY
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Amino Acids -->

Question Answer
OxaloacetateAspartate, Asparagine (DN)
PyruvateCysteine, Tryptophan, Alanine, Glycine, Serine, Threonine (CT WAGS)
Acetyl-CoALeucine, Tyrosine, Phenylalanine, Lysine, Tryptophan, Isoleucine, Threonine (LYFKWIT)
alpha-KGProline, Glutamate, Glutamine, Arginine, Histidine (PEQRH)
Succinyl-CoAMethionine, Isoleucine, Threonine, Valine (MITV)
FumaratePhenylalanine, Tyrosine (FY)
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--> Amino Acids

QuestionAnswer
alpha-KG->Glutamate -> Glutamine -> Proline
3-PGA-> Serine,->Glycine, -> Cysteine
Oxaloacetate->Aspartate -> Asparagine,
Pyruvate-> Alanine,
Phenylalanine->Tyrosine
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Screening Tests

QuestionAnswer
SensitivityTP / All with Disease (A / A + C)
SpecificityTN / All without Disease (D / B + D)
PPVTP / All P (A / A + B)
NPVTN / All N (D / C + D)
Col 1Disease Present
Col 2Disease Absent
Row 1Test +
Row 2Test -
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Porphyrias

Question Answer
ALADPB poisoning mimcs, like AIP, rare
AIP4 PBG --> preuro., cytosol, AD, mimicked by ALAD, HCP, VP: acute abd pain, neurop, red urine, EtOH/drug induced, urinary ALA/PBG, uro/copro // heme arg to supress heme biosyn
PCT4 decarb (UROD), cytosol, AD/Type I can be acquired: photosens, red urine, EtOH induced, liver disease, high Fe levels, urinary porphyrins // phleb, chloroquine
HCPacute symptoms like AIP, rare
VPacute symptoms like AIP + photosens, rare
EPPferrochelatase, mito, AD photosens at infancy, protoporph in feces // beta-carotene supresses
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Purine/Pyrimidine Components (C,N)

Question Answer
PurineG(2,1) Q(0,2) N10THF(2,0) D(0,1) CO2(1,0)
PyrimidineD(3,1) Q(0,1) CO2(1,0)
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Proteases

Question Answer
PepsinYFT (aromatic) stomach, self-cleavage
TrypsinKR (carbonyl) SI, enteropeptidase
ChymotrypsinYFT (aromatic) SI, trypsin converts from -ogen
Carboxypeptidasecarboxy terminal residues, pro-
Aminopeptidaseamino terminal residues (except P), no zymogen?
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Vitamins