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Epithelial cell junction components

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lilyo's version from 2016-06-03 19:38

Section

Question Answer
Tight junctionclaudin + occludins, prevents paracellular movement of solutes
Adherens junctionbelow tight junction, forms "belt" connecting actin cytoskeletons of adjacent cells with cadherens (Ca2+ dependent adhesion proteins), loss of E-cadherin --> metastasis
Desmosomestructural support via intermediate filament interactions, autoantibodies --> pemphigus vulgaris
Gap junctionchannel proteins called connexons permit electrical and chemical communication between cells
Hemidesmosomeconnects keratin in basal cells to underlying basement membranes; autoantibodies --> bullous pemphigoid
Integrinsmembrane proteins that maintain integrity of basolateral membrane by binding to collagen and laminin in basement membrane
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