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Epilepsy

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pharmd18's version from 2016-11-11 19:45

Section 1

Question Answer
carbamazepinnarrow
lamotriginebroad
levetiracetambroad
oxcarbazepinenarrow
phenobarbitalnarrow
phenytoinnarrow
topiramatebroad
valproic acidbroad
zonisamidebroad
memorize

Section 2

Question Answer
lamotrigine may worsen what type of seizuremyoclonic
valproic acid is drug of choice in what type of seizureabsence and myoclonic
therapeutic range for carbamazepine4-12
therapeutic range for phenobarbital15-45
phenytoin therapeutic range10-20
valproic acid therapeutic range50-100
carbamazepine adrslower sodium, weight gain, rash, blood dysgrasions,
lamotrigine adrsinsomnia, rash, well tolerated, less cognitive issues
levetiracetam adrsmood disorders, anxiety, adjitation, rash, blood dysgrasions
oxcarbazepine adrslower sodium, weight gain
phenobarb adrscns extensive (worst), lots of sedation and cognitive issues
phenytoin adrsanemia, hirsutism, gingival hyperplasia, cerebellar tox,
topiramate adrskidney stones, acidosis, weight loss, slightly more cognitive issues, taste disturbances
valproic acid adrsweight gain, hair loss, blood dysgrasions, liver failure, GI upset
zonisamide adrskidney stones, acidosis, weight loss, slightly more cognitive issues, taste disturbances
memorize

Section 3

Question Answer
carbamazepine DIinducer-auto
levetiracetam DI renally eliminated -doesnt inhbit liver enzymes
oxcarbazepine DI weak inducer
phenobarb DIinducer
phenytoin DIinducer
valproic acid DI inhibitor
memorize