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Epilepsy medsz

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olola's version from 2016-11-07 04:07

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Question Answer
side effects: osteomalacia, megaloblastic anemia, blood dyscrasia, allergies/rash, sedationBarbiturates (phenobarbital)
trigeminal neuralgiaCarbamazepine, Phenytoin
side effects: diploplia, ataxia, slurred speech, hallucinations, hematologic effects, dizziness, headacheCarbamazepine
undergoes oxidation and conjugation (renal excretion)Valproic acid
side effects: hepatotoxicity, tremor, inhibition of platelet aggregation, gingival bleedingvalproic acid
used mainly to treat status epilepticusIV administration of diazepam or lorazepam
used to treat LA-induced seizuresdiazepam
drugs control up to ________ of epileptic cases80%
drugs that can INDUCE liver microsomal enzymesphenobarbital, phenytoin, carbamazepine
drugs that INHIBIT liver microsomal enzymesvalproic acid, phenytoin (can induce and inhibit)
drug of choice for tonic-clonic and partial seizures is ______, also effective against them are ____phenytoin (drug of choice); phenobarbital, carbamazepine
contraindicated in pregnancyphenytoin
______ (prodrug) is endogenously metabolized into phenobarbitalprimidone
drug of choice for absence seizuresEthosuximide, esp. in conjunction w/ Valproate
Newer anticonvulsant drugsValproic acid, Carbamazepine, Diazepam
anticonvulsant drug chemically related to the TCAsCarbamazepine
used as prophylaxis for affective disordersCarbamazepine (chemically related to tricyclic antidepressants)
used as adjunct for refractory epilepsyGabapentin, Vigabartin, Tiagabine
used for convulsion prevention/control associated with eclampsia (seizures in pregancy)magnesium salts (e.g. magnesium sulfate)
broad spectrum drug, but more effective against absence and partial seizuresValproate
inhibit GABA transaminase (GABA-T), an irreversible inhibitor of enzymeVigabartin
a GABA analogue that doesn't interact with receptorGabapentin
T/F? Blood dyscrasias seen with most anticonvulsants, although rare, may increase the patient's susceptibility to infectionTrue
found in salivaSuccinimides (Ethosuximide), Hydantoins (Phenytoin)
accumulates in bonevalproic acid
seizures which characteristically occur in childhood, second most commonAbsence seizures, often responsive to drugs
most common variety of absence seizurepetit mal
phenyl substitution at R1 or R2phenytoin (desirable for tonic-clonic and partial seizures)
alkyl substitution at R1 or R2ethosuximide (desirable for absence seizures)
most common form of Generalized SeizuresTonic-Clonic (Grand Mal), usually responsive to drugs
epilepsy affects ____% of the population1%
seizures in which: consciousness impaired, but postural muscles NOT impairedabsence seizures (e.g. petit mal)
what are Jacksonian seizures?Simple partial seizures- involves one side of brain, consciousness not impaired
What are Complex partial seizures?psychomotor, temporal lobe seizures in which consciousness is impaired
prodrug Hydantoinfosphenytoin
cleft palate can be associated with this drugphenytoin (thus, contraindicated in pregnancy!)
phenytoin is ___% bound to plasma proteins, phenobarbital is ___% bound90%, 50%
decrease GABA uptake, used as adjunct for refractory epilepsyTiagabine
gingival bleeding associated withphenytoin, valproate
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