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Enzymes In Glycolysis

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Updated 2009-02-15 23:12

Enzymes in Glycolysis

Step/Reaction Enzyme
(1) Glucose + ATP ->
Glucose 6-Phosphate + ADP + H+
Hexokinase
(2) Glucose 6-Phosphate <=>
Fructose 6-Phosphate
Phosphoglucose Isomerase
(3) Fructose 6-Phosphate + ATP ->
Fructose 1,6-Bisphosphate + ADP + H+
Phosphofructokinase
(4) Fructose 1,6-Bisphosphate <=>
Dihydroxyacetone Phosphate +
Glyceraldehyde 3-Phosphate
Aldolase
(5) Dihydroxyacetone Phosphate <=>
Glyceraldehyde 3-Phosphate
Triose Phosphate Isomerase
(6) Glyceraldehyde 3-Phosphate + Pi + NAD+
<=> 1,3-Bisphosphoglycerate + NADH + H+
Glyceraldehyde 3-Phosphate Dehydrogenase
(7) 1,3-Bisphosphoglycerate + ADP <=>
3-Phosphoglycerate + ATP
Phosphoglycerate Kinase
(8) 3-Phosphoglycerate <=>
2-Phosphoglycerate
Phosphoglyceromutase
(9) 2-Phosphoglycerate <=>
Phosphoenolpyruvate + H2O
Enolase
(10) Phosphoenolpyruvate + ADP + H+ ->
Pyruvate + ATP
Pyruvate Kinase
memorize

 

Reference: p.357 of Lubert Stryer's "Biochemistry" 3rd Edition, 1988, W. H. Freeman, New York (ISBN=0-7167-1843-X).

Glycolysis versus Gluconeogenesis

Glycoslysis converts glucose into pyruvate.

Gluconeogenesis converts pyruvate into glucose.

Nevertheless, Gluconeogenesis is not a reversal of Glycolysis.
Glycolysis EnzymeGluconeogenesis Enzyme
HexokinaseGlucose 6-Phosphatase
PhosphofructokinaseFructose 1,6-bisphosphatase
Pyruvate KinasePyruvate Carboxylase
Phosphoenolpyruvate Carboxykinase
memorize

 

Reference: pp.439-440 of Lubert Stryer's "Biochemistry" 3rd Edition, 1988, W. H. Freeman, New York (ISBN=0-7167-1843-X).