Create
Learn
Share

Enzymes In Fatty Acid Synthesis

rename
Updated 2009-02-15 23:15

Enzymes in Fatty Acid Synthesis

Step/Reaction Enzyme
(1) Acetyl CoA + HCO3- + ATP ->
Malonyl CoA + ADP + Pi + H+
Acetyl CoA Carboxylase
(2) Acetyl CoA + ACP <=>
Acetyl-ACP + CoA
Acetyl Transacylase
(3) Malonyl CoA + ACP <=>
Malonyl-ACP + CoA
Malonyl Transacylase
(4) Acetyl-ACP + Malonyl-ACP ->
Acetoacetyl-ACP + ACP + CO2
Acyl-Malonyl-ACP Condensing Enyzme
(5) Acetoacetyl-ACP + NADPH + H+ <=>
D-3-hydroxybutyryl-ACP + NADP+
β-Ketoacyl-ACP-Reductase
(6) D-3-Hydroxybutyryl-ACP <=>
Crotonyl-ACP + H2O
3-Hydroxyacyl-ACP-Dehydratase
(7) Crotonyl-ACP + NADPH + H+ ->
Butyryl-ACP + NADP+
Enoyl-ACP Reductase
memorize

 

Reference: p.483 of Lubert Stryer's "Biochemistry" 3rd Edition, 1988, W. H. Freeman, New York (ISBN=0-7167-1843-X).