Enzymes In Fatty Acid Synthesis

Enzymes in Fatty Acid Synthesis

Step/Reaction	Enzyme
(1) Acetyl CoA + HCO3- + ATP -> Malonyl CoA + ADP + Pi + H+	Acetyl CoA Carboxylase
(2) Acetyl CoA + ACP <=> Acetyl-ACP + CoA	Acetyl Transacylase
(3) Malonyl CoA + ACP <=> Malonyl-ACP + CoA	Malonyl Transacylase
(4) Acetyl-ACP + Malonyl-ACP -> Acetoacetyl-ACP + ACP + CO2	Acyl-Malonyl-ACP Condensing Enyzme
(5) Acetoacetyl-ACP + NADPH + H+ <=> D-3-hydroxybutyryl-ACP + NADP+	β-Ketoacyl-ACP-Reductase
(6) D-3-Hydroxybutyryl-ACP <=> Crotonyl-ACP + H2O	3-Hydroxyacyl-ACP-Dehydratase
(7) Crotonyl-ACP + NADPH + H+ -> Butyryl-ACP + NADP+	Enoyl-ACP Reductase
	memorize

 

Reference: p.483 of Lubert Stryer's "Biochemistry" 3rd Edition, 1988, W. H. Freeman, New York (ISBN=0-7167-1843-X).