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Enzymes In Fatty Acid Oxidation

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Updated 2009-02-15 23:05

Enzymes in Fatty Acid Oxidation

Step/ReactionEnzyme(s)
(1) Fatty Acid + CoA + ATP <=>
Acyl CoA + AMP + Pi
Acyl CoA Synthetase
(also called Fatty Acid Thiokinase and
Fatty Acid: CoA Ligase [AMP])
(2) Carnitine + Acyl CoA <=>
Acyl Carnitine + CoA
Carnitine Acyltransferase
(3) Acyl CoA + E-FAD ->
trans-Δ2-enoyl CoA + E-FADH2
Acyl CoA Dehydrogenases
(several enzymes having
different chain-length specificity)
(4) trans-Δ2-enoyl CoA + H2O <=>
L-3-hydroxyacyl CoA
Enoyl CoA Hydratase
(also called Crotonase or
3-Hydroxyacyl CoA Hydrolyase)
(5) L-3-Hydroxyacyl CoA + NAD+ <=>
3-Ketoacyl CoA + NADH + H+
L-3-Hydroxyacyl CoA
Dehydrogenase
(6) 3-Ketoacyl CoA + CoA <=>
Acetyl CoA + Acyl CoA
(shortened by C2)
β-Ketothiolase
(also called Thiolase)
memorize

 

Reference: p.476 of Lubert Stryer's "Biochemistry" 3rd Edition, 1988, W. H. Freeman, New York (ISBN=0-7167-1843-X).