Endo Tumors

theyak89's version from 2016-06-02 18:57


Question Answer
Cushing disease. ACTH secreting pituitary adenoma. Increase ACTH
HTN, Hypokalemia, metabolic alkalosis, low plasma renin. Normal aldosterone. Aldosterone secreting adenoma (Conn)
<4 years old. Neural crest cells. Abd distention from firm mass. Can cross the midline (versus Wilms) HVA in urine. Bombesin +. N-myc geneNeuroblastoma
Derived from chromaffin cells. Episodic HTNPheochromocytoma
Associated with VHL, Men 2A, Men 2BPheochromocytoma
Most common thyroid cancer. Empty appearing nuclei (orphan annie), psammoma bodies, nuclear grovesPapillary carcinoma
Thyroid mass with RET and BRAF mutations. Hx of radiationPapillary carcinoma
Invades thyroid capsule, uniform folliclesFollicular carcinoma
From Parafollicular C cells. Produces calcitonin. Sheets of cells in amylod stroma. Men 2A, 2b. RET mutationsMedullary Carcinoma
Older patients, thyroid mass, invades, poor prognosisAnaplastic carcinoma.
Hypercalcemia, hypercalcuria, hypophosphatemia. Increase PTH, ALP, and CAMP in ruineParathyroid adenoma
Bitemproal hemianopia, headache, hypopituitarismPituitary adenoma (non-functional)
Amenorrhea, glactorhea, low libdo, infertilityProlactinoma
AcromegalySomatotrophic adenoma
Diarrhea, cutaneous flushing, wheezing, right sided valvular disease, pellagraCarcinoid tumor or lung.
Parathyroid tumor, Pituitary tumor, Pancreatic endocrine tumors (ZE,VIP)MEN 1
Medullary thyroid carcinoma, Pheo, Parathyroid hyperplasiaMEN 2A
Medullary thyroid carcinoma, Pheochromocytoma, Oral/intestinal ganglioneuromatosis, marfinoidMEN 2B