Create
Learn
Share

Elongation

rename
fiyajoki's version from 2016-11-14 15:38

Section

On lagging strand primosome joins and strands immediately coated by SSB.
Synthesis catalysed by pol 3 holoenzyme, lagging after priming by primosome associated primase
Synthesis occur on a replisome; containing 2 pol 3 cores (alpha e theta subunits) linked by tau subunits, lagging strand looped around.
After synthesis of OK2 fragment, HE complex relocates to a new primer near RF. Previous primer is excised by pol 1 and DNA ligase seals the nick