separates the nuclear contents from the cytoplasm. Controls traffic of proteins and RNAs through nuclear pores and plays a critical role in regulating gene expression.
#Structure of the nuclear envelope?
Two nuclear membranes, an underlying nuclear lamina, nuclear pore complexes. Outer membrane is continuous with the ER.
What does the lamina do?
keeps the structure of the cell. fibrous mesh that provides structural support, consists of proteins called lamins(fibrous proteins).
#what do mutations in lamins do?
Causes mutations in growth structures/proteins.
How are lamins coded for/lamina made?
Mammals have 3 lamin genes which code for 7 proteins. 2 of these proteins interact to form a dimer, the alpha helical regions wind around each other to form a coiled coil. Lamin dimers associate with each other to form the lamina.