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Dyslipidemia

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yecijone's version from 2017-07-12 05:19

Dyslipidemia

genericBrandClassdrug pearls
atorvastatinLipitorHMG-CoA inhibitor10-80mg qd Anytime, CI active liver disease --> monitoring LFTs, pregnancy & breast feeding, Warning skeletal muscle effects, SE myalgias, arthralgias, myopathy, *** MAX 20 qd With azole, HIV PI
atorvastatin + amlodipineCaduetHMG-CoA inh + CCB
atorvastatin + ezetimibeLiptruzetHMG-CoA inh + cholesterol absorption inhibitor
fluvastatinLescol, Lescol XLHMG-CoA inhibitorIR take at night, XL anytime, CI active liver disease --> monitoring LFTs, pregnancy & breast feeding, Warning skeletal muscle effects, SE myalgias, arthralgias, myopathy
lovastatinMevacor, AltoprevHMG-CoA inhibitor20-80mg qd --> **** IR has to take with EVENING MEAL, ER qHS, CI active liver disease --> monitoring LFTs, pregnancy & breast feeding, *** CI- Strong 3A4 inhibitor, Warning skeletal muscle effects, SE myalgias, arthralgias, myopathy, **** with verapamil, diltiazem, dronedarone, amlodipine MAX 20mg qd; with amiodarone, ticagrelor MAX 40mg qd
pitavastatinLivaloHMG-CoA inhibitortake ANYTIME, CI active liver disease --> monitoring LFTs, pregnancy & breast feeding, Warning skeletal muscle effects, SE myalgias, arthralgias, myopathy
pravastatinPravacholHMG-CoA inhibitortake ANYTIME, CI active liver disease --> monitoring LFTs, pregnancy & breast feeding, Warning skeletal muscle effects, SE myalgias, arthralgias, myopathy
rosuvastatinCrestorHMG-CoA inhibitor5-40mg qd Anytime, CI active liver disease --> monitoring LFTs, pregnancy & breast feeding, Warning skeletal muscle effects, SE myalgias, arthralgias, myopathy, *** MAX 10 qd With azole, HIV PI
simvastatinZocorHMG-CoA inhibitor10-40mg qd at night, CI active liver disease --> monitoring LFTs, pregnancy & breast feeding, *** CI- strong 3A4 inhibitor, PLUS conivaptan, tacrolimus, gemfibrozil, Warning skeletal muscle effects, SE myalgias, arthralgias, myopathy, **** with verapamil, diltiazem, dronedarone MAX 10mg qd; with amiodarone, amlodipine, ranolazine MAX 20mg qd
simvastatin + ezetimibeVytorinHMG-CoA inh + cholesterol absorption inhibitor
ezetimibeZetiacholesterol absorption inhibitor10mg qd, CI severe liver disease, pregnancy/breastfeeding, Warning use in moderate-severe liver disease, SE diarrhea, arthralgia, myalgias, sinusitis
colesevelamWelcholBile acid sequestrantCI TG>500, bowel obstruction, pancreatitis, SE "constipation", abdominal pain, bloating *** it could increase TG, **** Preferred in Pregnancy --> cat.B
cholestryramineQuestranbile acid sequestrant4g packet mixed with water --> *** do NOT sip or hold in your mouth --> Teeth discoloration & decay, SE "constipation", abdominal pain, bloating *** it could increase TG
colestipolColestidbile acid sequestrantSE "constipation", abdominal pain, bloating *** it could increase TG
fenofibrateAntara (micronized), Lofibra (micronized) Trilipix, Fibricor, TricorPPAR-alpha activator** all QD with Food, *** CI severe liver disease, renal impairment, gallbladder disease, "Nursing mother", Warning myopathy, cholelithiasis, SE increased LFTs, increased CPK, dyspepsia
gemfibrozilLopidPPAR-alpha activatorONLY fibrate taken BID --> 30m before breakfast and dinner, *** CI severe liver disease, renal impairment, gallbladder disease, "Nursing mother", *** do NOT give with simvastatin, ezetimibe, tizanidine
niacinNiacor (IR-OTC), Niaspan (ER), Slo-Niacin (SR, DR)vitamin B3 - decrease hepatic sysnthesis of VLDLER 500mg qHS x 4w, CI active liver disease, Warning hepatotoxicity, SE "flushing", pruritus, hyperglycemia, HYPERURICEMIA (gout), ***SR&DR have LESS flushing but MORE hepatotoxicity, *** ER has LESS flushing & hepatotoxicity
omega-3Lovazafish oil4c qd, *** indicated for TG>500, SE burping, dyspepsia, taste perversion **** can increase LDL & increase bleeding time --> monitor INR with warfarin, ** Other types are Vascepa, Epanova, Omtryg
alirocumabPraluentPCSK975-150mg SQ q2w, SE injection site reaction
evolocumabRepathaPCSK9140mg SQ q2w, SE injection site reaction
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