phrm1013's version from 2016-05-11 18:59


This page can help you learn some information about drugs for hyperlipidemia.


Question Answer
MOA of ezebutide (Ezetrol®)interferes with active absorption of dietary cholesterol within the small intestine, leads to removal of LDL from blood by the liver
Pharmacological class of gemfibrozil (Lopid®)Fibrate (hypolipidemic)
Auxiliary label for lovastatin (Mevacor®)Take with food AND Avoid grapefruit
MOA of atorvastatin (Lipitor®)Competitive inhibitor of HMG CoA Reductase, results is lowering of LDL and TG, and increase in HDL
Cholestyramine (Olestyr®) administration restrictions (meds)1 hour before or 4-6 hours after all medications except ASA, carbamazepine and phenytoin
Common adverse effect of cholestyramine (Osestyr®)constipation, bloating, nausea, gas (GI distress)
Immediate release formulations of Niacin cause _______flushing
Slow release formulations of Niacin cause _______ hepatotoxicity
Prevention of Niacin flushPredose with ASA and/or low dose and build tolerance


Question Answer
Process of atherosclerosisHardening and narrowing of blood vessels, LDL  oxidation  foam cells  fatty streak  hard plaque
Name of the test to determine LDL targetsFramingham Risk Score
Adverse effects of statinsMyalgia (rare rhabdomyolysis), peripheral neuropathy, liver enzyme increases
3 statins that interact with grapefruitAtorvastatin, lovastatin, simvastatin
Statin that cannot be crushed or chewedfluvastatin (Lescol®)
Fibrates mostly lowerTriglycerides
Fibrate that must be taken with foodbezafibrate (Bezalip®), fenofibrate (Lipidil®)
30 minute before meals fibrategemfibrozil (Lopid®)
Dietary recommendations for NiacinAvoid spicy, hot or alcoholic foods at the time of dose
MOA of bile acid sequestrantsinterfere with the enterohepatic recirculation of bile salts by binding bile in the colon