Drugs 4 Albin

gefigupo's version from 2015-09-25 15:08


Question Answer
DaptomycinRapid depolarization of cell membrane → disruption of DNA,RNA synthesis → cell death.
Daptomycin DxVancomycin Resistant, MRStaph Aureus, Cornybacteria
Daptomycin SxDiarrhea, Nausea, Rhabdomyolysis
TrimethoprinInhibits bacterial dihydrofolate reductase(pyrimidine synthesis)- converting dihydrofolic - tetrahydrfolic
Trimethoprin DxTMP-SMX → UTI, Shigella, Salmonella, Pneumocystis Jirovecii(<200 Aids Prophylaxis)
Trimethoprin SxMegaloblasticAnemia, Steven Johnson Syndrome, Toxic epidermal necrolysis, Leukopenia, Granulocytopenia, Sulfa Allergy
RifampinInhibits DNA dependant RNA polymerase. Rapid resistance if used by itself(Altered structure of bacterial ribosomal proteins).
Rifampin DxMycobacterium TB, Leprosy, Meningococcal Prophylaxis(MONOTHERAPY).
Rifampin SxRed orange or orange body fluids, Hepatotoxic.
IsoniazidDecrease synthesis of Mycolic acids. Mutation causes resistance becauses KatG(BACTERIAL Catalase peroxidase) needed to activate isoniazid. 2. Modification of the protein target binding site.
Isoniazid Dx Mycobacterium TB and Prophylaxis of TB
Isoniazid SxNeurotoxicity can be prevented by giving b6, SLE, Hepatits(Hepatocyte damage) G6PD, Seizures
Isoniazid AntidotePyridoxine
PyrazinamidePyrazinamidase → pyrazinoic acid. (Requires and Acidic Environment to kill TB inside the phagosome of macrophages and other intracellular organisms)
EthambutolEthambutol-arab-carbohydrate Blocks Arabinosyltransferase → Decreases Carbohydrate polymerazation of cell wall. Mutation causes resistance Increases acitivty of enzymes involved in cell wall polysaccharide synthesis.
Ethambutol SxOptic Neuropathy/ Red green color blindness.
StreptomycinTB drug. Resistance caused due to altered structure of bacterial ribosomal protein
StreptomycinInhibits initiation of protein synthesis by binding to and distorting the structure of prokaryotic 30 s ribosomal subunit


: Antifungal
Question Answer
Amphotericin B Binds ergosterol and forms leaky membrane pores TOPICAL
Amphotericin B DxCyptococcus, Blastomyces, Coccidioides, Histoplasma, Candida, Mucormycosis.
Amphotericin B SxRenal Toxicity, Optic Neuropathy, Redgreen color blindness
Amphotericin B Major SxSerum potassium and magnesium needs to be monitored.
FlucytosineFluctysoine converted to 5-FU in fungal cells → Inhibits DNA and RNA synthesis.
Flucytosine DxCryptococcal Meningitis with Ampotericin b
NystatinBinds ergosterol and forms leaky membrane pores TOPICAL
Nystatin DxCandidiasis, topical- Diaper rash, Vaginal Candidiasis.
AzolesInhibit 14α-demethylase, a cytochrome P450 enzyme required for ergosterol synthesis.
Azoles DxCryptococcal Meningitis in AIDS, Blastomyces, Coccidioides, Histoplasma, Candida.
Azoles SxInhibiton of testosterone synthesis → Gynocomastia. Liver dysfunction → Inhibit P450.
TerbinafineInhibits Fungal Squalene Epoxidase → Ergosterol Synthesis Inhibited
Terbinafine DxDermatophyte infections TOPICAL
Terbinafine SxAbnormal Liver function tests & Visual Disturbances
GriseofulvinBinds to microtubules → Disrupts mitotic spindles.
Griseofulvin DxSuperficial infections, Dermatophyte infections TOPICAL
Griseofulvin SxCarcinogenic, Teratogenic, Confusion, headache, Induce p450


: Anti-protozoan
Question Answer
ChloroquineBlocks detoxification of Heme → Heme accumulates
chloroquine DxPlasmodial infections except P.falciparum
Chloroquine SxRetinopathy
Pyrimethamine and SulfadiazineToxoplasma gondii – HIV – Ring or spherical frontal lobe calcifications MRI
Primaquine ALWAYS+ WITH chloroquineFOR P.Vivax & P.Ovale = Prevent Disease relapse due to intrahepatic stages.
MebendazoleEnterobiasis FIRST-LINE
MefloquineFirst line for Plasmodium


: Viral
Question Answer
ZanaMiViR, OseltaMiViRInhibit Influenza neuraminidase → decreased Membrane Viral Release (Lysogeny), viron particle release
ZanaMiViR, OseltaMiViRDxInfluenza A&B = Prevention and treatment
ZanaMiViR, OseltaMiViRSxRetinopathy
RibavirinCompetivily inhibit IMP Dehydrogenase → Inhibit synthesis of guanine Nucleotides → interfere with duplication Viral genetic material
Ribavirin DxRSV, Chronic Hepatitis C
Ribavirin SxHemolytic Anemia, Extremely Teratogenic
AmantidineImpairs uncoating or disassembly of influenza
AcyclovirPurine nucleoside analogue → Viral thymidine kinase converts it into acyclo-GTP → Inhibits Viral DNA Polymerase & incorporation into viral DNA → chain termination.
Acyclovir DxHSV & VZV
Acyclovir SxRenal tube crystalline nephropathy – Adequate Hydration must be given
ValacyclovirGiven daily to prevent recurrence of HSV-2
FosCARnetPyrophosphate analogue that inhibits viral DNA polymerase by binding to pyrophosphate binding site of enzyme. No viral kinase required. Also inhibits NRTI
FosCARnet DxUsed in acyclovir/ganiciclovir-Resistant hsv, Cmv retinitis, advanced Aids
FosCARnet SxNephrotoxicity → Hypocalcemia, Hypomagnesemia,Hypokalemia → Seizures
ZidovudineUsed for general prophylaxis and during pregnancy to reduce transmission risk. Decrease vertical transmiZion. Sx Blasts your bonemarrow, Megaloblastic anemia
EnfuvirtideBind HIV gp-41 protein leading to preventing gp41 from allowing virus to fuse to target cellullar membrane
NNRTIBind to reverse transcriptase at a different site. Do not need a thymidine kinase to be activated. Does not need activation via intracellular phosphorylation.
NNRTI SxBone Marrow Suppression(G-csf), Peripheral Neuropathy, Lactic Acidosis(nucleosides), Rash(non-nucleosides), Megaloblastic anemia(ZDV)
NNRTI drugsNeVIRapine, EfaVIRenz, DelaVIRDINE
ProTEASE Inhibitors – “navirs”Inhibit viral in coded protease to cleave polyproteins → Prevent maturation
ProTEASE Inhibitors – “navirs SxHyperglycemia, GI intolerance, Lipodystrophy (FAT REDISTRUBITION - Cushing)
ProTEASE Inhibitors – “navirsLopiNAVIR, AtzaNAVIR, FozampreNAVIR,SaquiNAVIR
Integrase InhibitorInhibits HIV viral genome integration into host cell chromosome by reversibly inhibting HIV integrase → Impairs Messenger RNA Transcription
RalTEGRAvir Integrase Inhibitor SxHypercholesterolemia
Integrase Inhibitor DrugRalTEGRAvir


: Antidotes
Question Answer
MushroomsDeath cap – Aamanitin → inhibits RNA polymerase II “MRNA” → liver fail
AcetaminophenInhibit COX enzyme → Inhibiting pro-inflammatory chemicals. Metabolized by AM404 → Reuptake of Anandamide by neurons/ Inhibit Na Channel(Anesthetic) Normal – Conjugated by liver → N-acetylbenzoiminoquinone → Glutahione molecules reacts → Urine
Acetamenophen AbnormalLiver → ↑N-acetylbenzoiminoquinone → ↓Glutahione molecules → Zone III Centriolobular Hepatic necrosis.
Acetamenophen AntidoteN-acetylcysteine → glutahione precursor → ↑ Glutahione molecules for NAPQI
N-acetylcysteineAlso used in Cystic Fibrosis pts as mucolytic agent by cleaving or reducing the intermolecular disulfide bridges or bonds within mucus glycoproteins
N-acetylcysteine non toxicSulfhydryl group supplementation for acetaminophen toxicity
↑Iron - Hemachromatosis SxCNS, Bloody Diarrhea, Metabolic acidosis, Restrictive cardiopathy, joint pain, diabetes, skin bronze
Lead SxMicrocytic anemia, abdominal pain, purple lines on gingivia, Peripheral Neuropathy.
Lead AntidoteEdta, Dimercaprol
Methemoglobin “Chocolate apperance Blood”Sx Cyanosis, Fatigue, Confusion, Coma
MethemoglobinAntidoteMethylene Blue
ArsenicGarlic smelling breath, CNS, Mees Lines(white horizontal lines on fingernails
Copper – Skin yellow, Wilsons liver disease(low ceruloplasmin)Penicillamine
Mercury – Fish, fluorescent light bulbDimercarpol
Prinzmitel AnginaElevated ST segment with lead changes
ErgonovineUsed to test for prinzmitel Angina
CyanideSxAlmond scent breath, trismus, apnea, seizures, coma, cardia arrest.
CyanideTxAmynitrate – Convert to Methhemoglobin - > ferrous iron means cyanide binds more to ferrous iron and NOT mitochondrial enzymes = LESS DAMAGE
Nitropusside poisioning↑Cyanide → Metabolic Acidosis → ↑Venous po2 = REVERSE WITH SULFUR which increases-> Sodium thiosulfate coverts it to Thiocyanate → excreted
Bromodeoxyuridine (Thymidine)Increase uptake means high number of tumor cells in s phase waiting to replicate and signifies High grade


Question Answer Column 3
StatinsTreat High LdlHepatits, Myopathy
NiacinTreat low HdLCutaneous Vasodilation, Hyperuricemia(gout), Hyperglycemia(Acanthosis nigracians), Hepatits
FibratesTreat High TriglycerideGallstones, Myopathy(worse with statins)
Bile acid resinsTreat High LdLGI Upset, Hypertriglyeridemia, Malabsorption

MRSA Infection drugs

Question Answer
Vancomycinblocks glycopeptide polymerization by binding tightly to d-ala-d-ala
VancomycinRedman Syndrome, Nephrotoxicity
DaptoMYCINDepolarization of cellular membrane
DaptoMYCINMyopathy and CPK elevation
DaptoMYCINInactivated by pulmonary surfactant
linezolidBinds to 50s and inhibits protein synthesis
LinezolidThrombocytopenia, Optic Neuritis, Risk for serotonin Syndrome
C.difficileMetrondiazole, vancomycin, Fidaxomicin
Severe CdifficileVancomycin
Recurrent CdifficileFidaxomicin
FidaxomicinOral drug with minimal systemic absorpotionand less affecton normal colon than vancomycin and metrondiazole


Question Answer
TetracyclinesTeeth Discoloration
AspirinNeonatal Bleeding
CocaineFetal growth retardation
AlcoholFetal Alcohol Syndrome (Mental retardation, mid face abnormalities)
DiabetesCaudal Regression Syndrome (sacrum and lumbar not developed leading to flaccid paralysis/absent ankle reflex)
MarijuanaLow birth weight babies


Question Answer
PhencyclidineNystagmus, Violent behavior,ataxia
LSDVisual Hallucinations
CoccaineChestpain, seizures
MethamphetamineToothdecay, Tachycardia, diaphoresis, violent behavior, choreiform movements
MarijuanaIncrease Appetite, Impaired Time perception, Conjunctival injection
HeroinDepressed mental status, Miosis, Respiratory depression
Alcohol withdrawal DOCDiazapam & Chlordiazepoxide


Question Answer
MOAAllosteric binding to the gaba receptor and increasing the frequency of ion channel opening
ZolpidemLeast addictive sleeping aid


: Antiandrogens
Question Answer
Finasteride moa5a reductase inhibitor → ↓testosterone to DHT → Decrease in ONLY DHT levels. Dx Baldness, B+PH
Finasteride SxGyncomastia
Flutamide moaCompetitive Inhibitor of testosterone receptor and DHT → Dx prostate carcinoma
Ketoconazole moaInhibits 17,20 Desmolase → Dx In Poly Cystic Ovarian Disease Prevent Hirsuitism
Spirnolactone moaInhibits androgen receptor with its interaction with DHT
Spirnolactone SxGyncomastia, Hair Loss


: Dopaminergic
Question Answer Column 3
Mesolimbic - MesocorticalRegulates BehaviorSchizophrenia
NigrostriatalCordination of voluntary movementsParkinsonism
TuberoinfundibularControls Prolactin secretionHyperprolactinemia


Beta blocker sideffect
Question Answer Column 3
BronchicBronchoconstriction and can asthma or COPD worseB2 Blocker
Muscle vasculatureVasospasm Make peripheral artery disease worseB2 blocker
Glucagon SecretionDiminished in pts with DMB2 Blocker
Heart ONLYB1 BlockerDecrease Sa & Av Node helpful in atrial arythemias
Heart OnlyB1 blockerReduce O2 consumption leading to less angina in MI
Heart OnlyB1 BlockerDecrease HR & Contractility to lower BP
Insulin inhibitedA receptorStimulated
Insulin secretedB & H2 receptorStimulated