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Drug Lists

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bananas's version from 2015-07-13 16:51

Dosing

Question Answer
Low therapeutic indexLithium, Digoxin, Warfarin, Phenobarbitol
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Suffixes

Question Answer
-afilPDE-5 inhibitors: Sildenafil, tadalafil [remember fil's penis]
-azinePhenothiazine (neuroleptics, antiemetics): Chlorpromazine, thioridazine, promethazine
-operidolNeuroleptic: Haloperidol, Droperidol
-dipineDihydropyridine CCB (Decrease SVR and arterial pressure): Nifedipine, Amlodipine
-dronateBisphosphonates (Osteoporosis - inhibit osteoclasts): Alendronate, Risedronate
-oxetineSSRI: Fluoxetine, Paroxetine (+Sertraline)
-fluraneInhaled anesthetics: Isoflurane Sevoflurane [up the flu!]
-gliptanDDP-IV inhibitor (DM2: inhibit glucagon): Sitagliptin, Saxagliptin [GLucagon clippers]
-glitazoneThiazolidinedione: Pioglitazone, Rosiglitazone [Glittering insulin receptors for DM2]
-ipramineTCA (antidepressant): Clomipramine, Imipramine
-triptylineTCA (migraine): Amitriptyline, Nortriptyline
-phyllineMethylxanthine (Inhibits PDE, used for COPD): Theophylline, Aminophylline
-prostProstaglandin analog: Latanoprost, Travoprost [-Prost for Prost-aglandin]
-terolBeta-agonist: Albuterol, Salmeterol
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Question Answer
-azepamBenzodiazepine: Lorazepam, Diazepam
-azolamBenzos: Alprazolam, Midazolam, Triazolam
-barbitalBarbituates: Phenobarbital, Secobarbital
-bendazoleBenzimidazole (anti-parasites): Mebendazole, Albendazole [remember bendy worms]
-caineLocal anesthetics: Lidocaine, tetracaine [remember cocaine]
-cholMuscarinic agonist (+): Bethanechol, carbachol
-cillinPenicillin: Amoxicillin, Methicillin
-conazoleImidazole (antifungal): Fluconazole, ketoconazole [remember cones from sketchy]
-curiumnon-depolarizing NMJ blocker: Atracurium, Mivacurium
-curoniumnon-depolarizing NMJ blocker: Vecuronium, Rocuronium
-cyclineProtein synthesis inhibitor (Binds 30S subunit): Tetracycline, Doxycycline
-mabMonoclonal AntiBody: Infliximab, Rituximab
-mustineNitrosurea (nitrogen mustard -- alkylating agent used in brain cancers): Lomustine
-navirProtease inhibitor (HIV): Ritonavir, Saquinavir
-ololBeta blocker: Atenolol, Metoprolol, Propanolol
-prilACE inhibitor: Enalapril, Lisinopril
-sartanAngiotensin Receptor Blocker: Losartan, Valsartan
-stigmineAnti-cholinesterase (Indirect muscarinic agonists): Neostigmine, Physostigmine, Rivastigmine
-tidineH2 blockers: Cimetidine, Ranitidine
-tropinPituitary hormone: Somatotropin, Thyrotropin (TSH)
-zosinalpha-1-antagonist: Prazosin, Doxazosin
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Side Effect Profile

Question Answer
FlushingVancomycin (red man), Adenosine, Niacin, dihydropyridine CCB [VANC]
Coronary VasospasmCocaine, Amphetamines, Sumatriptan, Ergotamine
Dilated cardiomyopathyDoxorubicin, Daunorubicin [anti-cancer]
Torsades de pointes (prolonged QT)Potassium channel blockers (class III)
Sodium channel blockers (class 1a)
Macrolides
Haloperidol
Chloroquine (anti-malaria)
Protease inhibitors
Ondansetron
CV collapse, Lactic acidosis, Bright red blood, Altered MSContinuous infusion of nitrates: Cyanide toxicity
Serotonin syndrome (tachycardia, myoclonus, tremor, ms change)Linezolid
Ondansetron
Tramadol
Triptan
SSRI/SNRI
[LOTTS of Serotonin]
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Question Answer
ThrombocytopeniaHeparin (HIT), Cimetidine
AgranulocytosisGancyclovir, Dapsone, C(Clozapine, Carbamazepine, Colchecine), Methimazole, PTU [Gangs Do CCCrush Myeloblasts and Promyeloblasts]
Aplastic anemiaChloramphenicol, Methimazole, NSAIDs, Benzene, PTU
[Can't Make New Blood Properly]
Gray baby syndrome (vomit, ashen , CV collapse, limp)Chloremphenicol
(immature UDP-glucoronyl transferase results in toxic metabolites accumulation)
Hemolysis in G6PD deficiencyFava beans, Dapsone, Isoniazid, Sulfonamides, Primaquine, ASA (high dose), Ibuprofen, Nitrofurantoin, Napthalene
[Fuck DIS PAIN]
ThrombosisOCP's (smokers >35 y.o), HRT, Celecoxib
Megaloblastic anemiaPhenytoin, Methotrexate, Sulfa
[have a BLAST with PMS!]
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Question Answer
Pulmonary fibrosisAmiodarone, Bleomycin, Busulfan (anti-Cancer) [ABC's]
CoughACE inhibitors (bradykinin)
Methemoglobineia (cyanosis and chocolate blood)Nitrites/Nitrates
Benzocaine/Lidocaine
Antimalarial (Chloroquine, Primaquine)
Dapsone, Sulfonamides, Metoclopramide
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Question Answer
Pseudomembranous colitisClindamycin, Amoxicillin/ampicillin
Hepatic necrosisHalothane, Acetaminophen, Valproic acid, Amanita phalloides
HepatitisRifampin, Isoniazid, Pyrazinamide, Statins, Fibrates
[RIPS Fibers in the liver]
Increased triglyceridesCholestyramine (bile-binding resins)
Gastric ulcersNSAIDs, Aspirin, radiation
Metabolized at zero-order kineticsPhenytoin, Ethanol, Aspiring [PEA like O]
Acute PancreatitisRitonavir, NRTI's (HIV), Sulfa drugs
Biliary colicOpioids: contract SM in sphincter of oddi
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Question Answer
Tertiary adrenal insufficiencyCortisol withdrawal
GynecomastiaSpironolactone, THC, Alcohol, Cimetidine, Ketoconazole, Estrogens, Digoxin [STACKED]
Hot flashesTamoxifen, Clomiphene
HypothyroidismSulfonamides, Amiodarone, Lithium [SAL was hypothyroid]
HyperglycemiaNiacin, CorticoSteroids, HCTZ, Tacrolimus, Protease inhibitors [Need to Check Sugars when you Have These Pills]
Anti-cholinergic side effectTypical neuroleptics (Thioridazine, Chlorpromazine), TCA (Amitriptyline), Antihistamine (Diphenhydromine, Hydroxyzine), Amantadine
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Question Answer
GoutDiuretics [loop and thiozide], Niacin, Cyclosporine Pyrazinamide
Gingival hyperplasiaPhenytoin, Verapamil
OsteoporosisCorticosteroids, Heparin
PhotosensitivitySulfonamides, Amiodarone, Tetracycline [SAT for the PHOTO]
Stevens-Johnson syndromeCarbamazepine, Lamotrigine, Allopurinol, Phenytoin, Phenobarbital, Penicillin, Ethosuximide, RASH, Sulfa drugs [CLAPPPERS]
Drug-induced lupusSulfonamides, Hydralazine, Isoniazid, Procainamide, Phenytoin [SHIPP]
Tendon ruptureFluoroquinolones
MyopathyStatins (worse when combined with fibrates)
Daptomycin (high CPK)
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Question Answer
Interstitial nephritisNSAIDs, Furosemide, Aminoglycosides
Diabetes insipidusLithium, Demeclocycline
Fanconi syndrome (proximal tubules)Expired Tetracycline, Heavy metals, Wilson's
Hemorrhagic cystitisCyclophosphamide, Ifosfamide
SIADHCarbamazapine, Cyclophosphamide, SSRI [Can't Concentrate Serum Sodium]
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Question Answer
ParkinsonismAntipsychotics, Reserpine, Metoclopromide
[Cogwheel rigidity of the ARM]
Cinchonism (dizzy+headache+vision change+tinnitus)Quinidine, Quinine {Q's}
SeizuresBuproprion, Imipenem, Cilastatin, Isoniazid, Tramadol, Metoclopramide, Withdrawal (from benzos or alcohol)
[Bats and Mice in the WIITCh's Brew]
Tardive dyskinesiaAntipsychotics, Metoclopramide
Disulfiram-like Reaction (to alcohol)Metronidazole, Cephalosporins, Sulfonylureas (1st gen), Procarbazine]
[Miller, Corona, PBR and Sam adams]
Nephrotoxicity + NeurotoxicityCisplatin, Polymixins, AminoGlycosides
Nephrotoxicity + OtotoxicityAminoglycosides, Vancomycin, Loop diuretics, Cysplatin
Anticholinergic (dry as a bone, hot as a hare, red as a beet...)Atropine, Tricyclinc antidepressants, H1 blockers, Low-potency neuroleptics
AtaxiaBenzodiazepines: Long acting (Flurazapam, Diazepam) > Medium (Lorazepan) > Short (Alproazolam, Oxazepam, Triazolam)
Intracerebral hemorrhage [decreased consciousness, asymmetric pupils]Streptokinase (converts plasminogen > plasmin to dissolve fibrin)
Visual changes (Decreased visual acuity)Ethambutol
Optic neuritisLinezolid
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Antidotes

Question Answer
AcetaminophenN-acetylcysteine: Replenishes glutathione so liver can break down hepatotoxic metabolites NAPQI
AChE inhibitors
Organophosphate poison
Atropine
Pralidoxime: Re-activates acetylcholinesterase
Amphetamines (basic)Ammonium Chloride: acidifies urine in severe alkalosis
Anticholinergic agentsPhysostigmine, control hyperthermia
BenzodiazepinesFlumazenil: GABA antagonist
Beta blockersGlucagon: Increase cAMP
Carbon monoxide100% O2
Hyperbaric O2
Copper
Arsenic
Gold
Penicillamine
[Copper pennies]
CyanideNitrite + thiosulfate
Hydroxocobalamin
Digitalis (digoxin)Anti-dig Fab fragments
HeparinProtamine sulfate: binds Heparin
IronDeferoxamine: Iron chelator
Deferasirox
LeadEDTA
Dimercaprol
Succimer
Penicillamine
Mercury
Arsenic
Gold
Dimercaprol (BAL): Chelation
Succimer
Methanol or Ethylene glycol (antifreeze)Fomepizole
Ethanol
Dialysis
MethemoglobinMethylene blue
Vitamin C
Longterm: Cimetidine
OpioidsOpioid antagonist: Naloxone, Naltrexone
SalicylatesSodium Bicarbonate: alkalinze the urine
Dialysis
TCAsSodium Bicarbonate: Alkalinize plasma
tPA, streptokinase, urokinase (thrombolytics)Aminocaproic acid: Inhibits plasmin
WarfarinFresh frozen plasma (immediate)
Vitamin K (delayed effect)
Serotonin syndromeCyproheptadine: Serotonin antagonist
Octreotide for GI effects
Cyclophosphamide (Nitrosurea) induced hemorrhagic cystitisMesna: binds and inactivates chemo toxic metabolites
HIT (Heparin)Argatroban: Binds the thrombin active site
Lepirudin, Hirudin
Cyanide poisoning from NItroprusside infusion1. Hydroxocobalamin: bind cyanide ions
2. Sodium nitrite: induce methemoglobinemia
3. Sodium thiosulfate: detoxify sulfur donors
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