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Dosage Delivery Systems

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rpopple's version from 2016-08-27 01:13

Section

Question Answer
what is the advantage of capsules convenience of administration, accuracy and reproducility of dosing, increase drug stability and ease of mass production
t/f a capsule always only contains solid drug alonefalse. rarely does.
do is the function of diluents or fillers like lactose in a capsuleensure physical stability. they are added to the capsule and aid in the rapid dispersal of drugs into GI fluids
what does the opposite effect of diluents or fillers like lactoseLubricants like magnesium stearate. these are included in the capsule to make sure that the powder flows and doesnt clump up. Lubricants are hydrophobic and slow the drug dispersal into the GI fluids
what is the role of starch in a capsuleit is called a disintegrant. it is necessary for prompt capsule disintegration. They absorb water and the capsule ruptures
pros and cons of tablets ( compressionthe compression makes for a convenient and effective theroputic dose the con is drug delivery by tablets.
do capsules contain diluents, lubricants and disintegrants?yes!! makes for an ease of manufacturing and the in vivo performance of tablets
what is the major determinant of dissolution rate? solubility.
if you use a salt form of the drug, will that increase solubility?yes!!! salt is more soluble.
decreaseing the particle size of the drug will increase or decrease the solubiltyincrease
what does enteric coating do it will delay the disintegration of the dosage until it reaches the small intestines.
why do enteric coating?to either protect the drug from the acidic environment or to protect the stomach from the drug.
what is the enteric coating- coated with?the polymer cellulose acetate phthalate. it is insoluble at 1-3 PH but is 5 to 7
what is the advantage of slow intravenous injectionsit avoids excessively high transient cencentrations and minimizes sudden precipitations of insoluable drug aka reducing the risk of emboli
Prolonged Release Formations have the advantage of whatreducing dosage frequency while still maintaining therapeutic drug concentrations
memorize