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Diuretixxx

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valesoje's version from 2017-03-16 18:15

Section 1

Question Answer
mechanism of acetazolamideblock CA (carbonic anhydrase) in PCT - inhib NaHCO3
mechanism of loop diureticsblocks NKCC2 receptor in TAL
mechanis of thiazidesblock NCC channel in DCT at Cl- site
mechanism of amiloride and traimtereneblocks ENaC channel
mechanism of spironolactone and eplerenonecompetitive antagonist at aldosterone receptor
mechanism osmotic diureticsosmotically active that gets filtered by glom but not reabsorbed = water retention and high urine vol
mechanism of antidiuretic hormoneactivates V1 or V2 to increase watter reabsorp in collecting duct
mechanism of ADH antagonistinhibts effect of ADH by blocking V1 and v2
mechanism of caffeine/theophylineinhibit adenosine receptors > decrease NHE3 in PCT > diuretic activity and decrease K secretion in collecting tubule
memorize

Section 2

Question Answer
class of acetazolamidecarbonic anhydrase inhibitor
class of furosemideloop diuretic
class of bumetanideloop diuretic
class of ethacrynic acidloop diuretic
class of hydrochlorothiazidethiazide
class of clorthalidonethiazide
class of amiloridepotassium sparing
class of triamterenepotassium sparing
class of spironolactone/eplerenonepotassium sparing
class of mannitolosmotic diuretics
class of ADH/vasopressinADH
class of demsopressnADH
class of conivaptanADH antagonist
class of tolvaptanADH antagonist
memorize

Section 3

Question Answer
how to treat acute mountain sickeness, glaucoma, metabolic alkalosis, and urinary alkalizationacetazolamide
how to treat edema, heart failure, hypercalcemia, hyperkalemia, acute renal failure, kidney dzloop diuretics (DOC furosemide)
how to treat hypertension, heart failure, nephrolithiasis bc hypercalciuria, and nephrogenic diabetets insipidusthiazides (hydrochlorohiazide more potent)
how to treat mineralcorticoid excess or hyperaldosteronism, hypokalemia by other diureticspotassium sparing drugs
how to treat increase urine volume, or reduce intracranial/intraocular pressureosmotic diuretics
how to treat central diabetes insipidusADH
how to treat CHF and SIADHADH antagonist
memorize

Section 4

Question Answer
adverse effects of acetazolamidemetabolic acidosis, renal stone, renal K wasting, drowsiness, parasthesia, hypersens rxn to sulfa drugs, contraindic in CIRRHOSIS
adverse effects of loop diureticsfluid and electrolye loss!!!! metabolic alkalosis, ototoxicity, hyperuricemia, hypomagnesemia, allergic rxn
adverse effects of thiazidesmetabolic alkalosis, hyperuricemia, hyponatremia, hyperglycemia, hyperlipidemia, hypersens rxn (sulfa), hypercalcemia - unmask underlying issue
adversee effects of amiloridehyperkalemia (combine w thiazide to fix)
adverse effects of triamtereneacute renal fail, hyperkalemia (combine w thiazide to fix)
adverse effects of spironolactonetumorigenic!!!, gynecomastia, hyperkalemia
adverse effects of mannitolextracell vol expansion, dehydration/hypernatremia
adverse effects of ADH/desmopressinhyponatremia and seizures in OD, vasopress = vasoconstrict, CONTRA - coronary artery dz
adverse effects of conivaptanhypernatremia, dry mouth/thirst
adverse effects of tolvaptanhypernatremia, dry mouth (30 days admin bc hepatotoxic)
memorize

Section 5

Question Answer
which part of nephron do CA inhibitors target?PCT
which part of nephron do the thick ascending limb/looploop diuertics
which part of nephron do thiazides targetDCT
which part of nephron do potassium sparing drugs target?collecting tubule
memorize

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