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dopey's version from 2017-09-05 14:15

Section

Question Answer
AmiloridesK+ sparing diuretics / blocks Na channel
TriamtereneK+ sparing diuretics / blocks Na channels
HydrochlorothiazideThiazide
ThiazideBlocks NaCl pump in distal convoluted tubule
Loop diureticBlocks Na 2Cl K pump in thick ascending loop of Henle
AcetazolamideCarbonic Anhydrase inhibitor
MethazolamideCarbonic Anhydrase inhibitor
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Vasodilators

Question Answer
Hydalazinearterial vasodilator
Nitratesvenous vasodilator (arterial at higher doses)
Sodium nitroprussidearterial and venous vasodilator
Minodixil, diazoxidearterial vasodilator
ClonidineSympatholytics (reduce sympathetic outflow by activating alpha2)
MethyldopaSympatholyic (converted into intermediates that are agonists at a2)
ReserpineAdrenergic depleting agents (Block reuptake of NE at presynaptic nerve)
GuanethidineAdrenergic depleting agent (Enter presynaptic to push out NE - deplete)
TrimethaphanAdrenergic depleting agent (blocks competitively at nicotinic cholinoreceptors on postganglionic)
ClevidipineDHP CCB
FenoldopamSelective dopamine-1 receptor agonist (vasodilatory)
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Section

Question Answer
ALLHATACEI, CCB, thiazide are equal in usefulness
ONTARGETdo not use ACEI and ARB together
ACCOMPLISHcombo therapy (ACEI + CCB or ACEI + thiazide) is beneficial for high risk hypertensive patients
HYVETBP lowering drugs (thiazide) in elderly results CV benefits
ACCORDDM patients no difference for < 120 and < 140, so goal is <140
SPRINTaim for < 120 if tolerable (even for elderly + not frail)
HOPE-3No benefit of using antiHTN to prevent intermediate risk; benefit if > 140; statin therapy -> clear benefit for intermediate risk
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