Diphenhydramine HCL Hydrocloride (Benedryl)

paramedic's version from 2017-09-15 20:37


Question Answer
Classification Antihistamine
Mechanism of Action Competes w/ histamine at receptor sites, Reverse dystopia reactions (Extra pyramidal reactions)
Indications Anaphylaxis secondary to Epi, Mild-modetate allergic reactions, Dystopia reactions
Contraindications Hypersensitivity, Shock/ Hypotension, Headache injury, Patients on sedatives, Patients on ETOH (intoxication), Glaucoma, Asthma or COPD attack, Late stage pregnancy or lactating mothers
Side Effects Hypotension, Tachycardia, Palpitations, Wheezing, Mucous plugs, Drowsiness, Dry mouth, Nausea/ Vomiting, Headache, Seizures, Dilated pupils, Confusion
Interactions Alcohol, Sedatives, Tranquilizers
Routes of Administration IV, IM
Onset/ Duration IV1- 5 mins. / 3- 4 hours
Onset/ Duration IM10- 15 mins. / 3- 4 hours
Adult Dose25- 50 mg Slow IVP, 50- 100 mg IM
Pediatric Dose1- 2 mg/Kg Slow IV/ IO/ IM (Max 50 mg/bolus)
Additional Info Monitor Patient's for seizure/ Hypotension, Use caution w/ elderly patients
Add. Info: Signs of dystopia reactionsNurhaliza rigidity, muscle spasm of face, tongue, neck, jaw, and back. Thickening of tongue. Fixed upward/ sideways gaze, facial grimace, dysphasia, dysphagia