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Diabetic Drugs

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sgthuan's version from 2015-09-03 00:20

insulin - weight gain, hypoglycemia, 1.5-3.5

Question Answer
lisprohumalog (fast acting)
aspartnovolog (fast acting)
glulisineapidra (fast acting)
glargine U-100lantus (long acting)
glargine U-200toujeo (long acting)
detemirlevemir (long acting)
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Biguanides - AMPK (cell is hungry) weight loss or neutral, basal agent

Question Answer
metforminglucophage, glumetza, fortamet
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K-ATP channel modulators Sulfonylureas - weight gain, hypoglycemia, basal agent (irreversibly)

Question Answer
chlorpropamide1st gen, long acting, no longer used too much side effects "diabenese"
tolbutamide1st gen, rapid acting, "orinase"
tolazamidetolinase (1st gen)
glyburidemicronase (2nd gen)
glipizideglucotrol (2nd gen)
glimepirideamaryl (2nd gen)
repaglinideprandin (non-sulfonylureas - meglitinides)
nateglinidestarlix (non-sulfonylureas - meglitinides)
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meglitinides - postprandial agent (reversibly)

Question Answer
repaglinideprandin (more efficacous)
nateglinidestarlix
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Thiazolidinediones (Tzds) - basal agent, weight gain (fat), PPARy -> lipogenesis in adipose tissues, do NOT use with insulin

Question Answer
pioglitazoneactos
rosiglitazoneavandia (linked to CVD)
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SGLT2 inhibitors - basal agent, weight loss, GFR > 45

Question Answer
canagliflozininvokana (take with food)
dapagliflozinfarxiga
empagliflozinjardiance
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DPP-4 inhibitors (GLP-1) - postprandial agent, early in diabetes

Question Answer
sitagliptinjanuvia
saxagliptinonglyza
alogliptinnesina
linagliptintradjenta (no dose adjustment based on renal function)
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GLP-1 receptor agonists - basal agent, intestinal L type, 1st phase response

Question Answer
exenatidebyetta (postprandial agent)
exenatidebydureon (basal agent)
liraglutidevictoza (basal agent)
albiglutidetanzeum (basal agent)
dulaglutidetrulicity (basal agent)
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