Not something you can just look at and be like ohh it's autoimmune prob
Age of oneset of Autoimmune probs
usually at a young age but PF is middle aged to old!
Signalment of pemphigus foliaceous?
Middle aged to older dogs, no sex predilection, common in dobbies and rotties if given trimethroprim sulfa
What is the primary lesion of pemphigus foliaceus?
Pustule is the PRIMARY LESION and you will see ancantholytic cells on histopath surrounded by neutrophil! Ulcers and crusting can result
How to dx PF?
Biopsy the pustules!
What if you see acantholytic cells and bacteria?
Rid of the bacteria first because they can cause acantholytic cells to come in small amounts but can confuse the pathologist so treat the bac t first then send in the biopsy! R/O the deep pyo by doing this
What tick preventative can cause PF?
Amitraz! Also some systemic and topical meds
When do you need to rid of bacteria before doing a biopsy??
Macerated tissue culture because its targeting the deep bacteria so need to clean off the superficial bacteria
What area of the body does PF like to target?
IT LOVES THE FACE and the planum nasale. Can affect the entire body though including the paw pads and ears you can see severe crusting/pustules (slide 19)
How to dx?
Biopsy + histopath
What steroid to treat?
Steroids in 2-3x aggressive dose until remission. Taper off slowly and monitor chem and urine because steroids increase ALP and if you also see ALT increase you know liver dmg is happening.
What immuno suppresent used to treat PF?
Cyclosporin (azathiaprine is liver toxic dont use)
vesicles and ulcers and it's deep that pemphigus foliaceus
Prognosis of PEMPHIGUS VULGARIS?
poor/pray, hard to treat
What type of cells do you see on histopath for PEMPHIGUS VULGARIS? Tombstone cells and neutrophils.
How to dx? Bipsoy an intact vesicle but if not then biopsy the ulcers margin using the surgical ellipse biospy (should include part of the ulcer). Breaking a vesicle can make ulcers.ni
What is nikolskys sign? (slide 34)
Nikolsky sign is a skin finding in which the top layers of the skin slip away from the lower layers when slightly rubbed. found in pemphigus vulgaris