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Cytokines

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zufevizi's version from 2016-08-28 17:57

Major Cytokines

 

TH1 Cytokines
CytokineMajor SourceMajor Target CellsMajor Effects
IL-2TH1T-Cell, B-Cell, NK CellT-Cell proliferation
IFN - GammaTH1Macrophage/B-CellActivation/Class switching to IgG3 (opsonize and fix complement)
TNF - BetaTH1Macrophages/NK CellsActivation/Inflammation
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Perfect for defending against viral or bacterial attack in blood and tissues - produce cytokines that instruct innate and adaptive systems to produce cells and antibodies that are effective against invaders.

 

TH2 Cytokines
CytokineMajor SourceMajor Target CellsMajor Effects
IL-4TH2T-Cell, B-CellActivation/Differentiation IgM to IgE/Development (TH0 to TH2).
IL-5TH2B CellClass switching IgM to IgA
IL-6TH2T-Cell, B-Cell Fever/inflammation (Late differentiation)
IL-10TH2TH1Down-regulates the expression of TH1 cytokines, MHC class II antigens, and costimulatory molecules.
IL-13TH2B CellIgE synthesis
TGF - BetaTH2B CellClass switching IgM to IgA
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Proinflammatory Cytokines
CytokineMajor SourceMajor Target CellsMajor Effects
IL-1MacrophageEndothelial CellsFever, Inflammation, Increased Vascular Permeability
IL-6MacrophageT-Cell, B-CellAcute phase Protein synthesis
IL-8MacrophageNeutrophilChemotaxis
IL-12MacrophageTH1, NK CellDevelopment (TH0 to TH1) and Activation of NK cells
TNF - AlphaMacrophage, NK CellEndothelial CellsInflammation/Toxicity, Activation
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Cytotoxic T-Cell Cytokines
CytokineMajor SourceMajor Target CellsMajor Effects
TNF - BetaTCAll nucleated cells displaying recognized complexKilling
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Growth Factor Cytokines
CytokineMajor SourceMajor Target CellsMajor Effects
IL-3TH1Hematopoetic Stem CellsDiversification into myeloid progenitor cells
IL-7thymic/BM stromal cellsPro-B and T-CellsDifferentiation and proliferation of lymphoid progenitor cells.
GMCSFMacrophageStem CellsProduce granulocytes (neutrophils, eosinophils, and basophils) and monocytes.
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