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Cytokines

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bethimmunology's version from 2015-04-24 13:53

Major Cytokines

 

TH1 Cytokines
CytokineMajor SourceMajor Target CellsMajor Effects
IL-2TH1T-Cell, B-Cell, NK CellCell division of T-cells
IFN - GammaTH1Macrophage/B-CellActivation/Class switching to IgG3 (opsonize and fix complement), Activates NK cells, and macrophages
TNF - BetaTH1Macrophages/NK CellsActivation/Inflammation,
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Perfect for defending against viral or bacterial attack in blood and tissues - produce cytokines that instruct innate and adaptive systems to produce cells and antibodies that are effective against invaders.

 

TH2 Cytokines
CytokineMajor SourceMajor Target CellsMajor Effects
IL-4TH2T-Cell, B-CellActivation/Differentiation IgM to IgE, & IgG, proliferation of B cells & T-cells/Development (TH0cells to TH2cells),
IL-5TH2B CellClass switching IgM to IgA, proliferation of B cells, growth factor for Eosinophils
IL-6TH2T-Cell, B-CellFever/inflammation (Late differentiation), Acute-phase protein synthesis, T-cell activation & IL-2 production, B-cell Ig production and hematopoetic progenitor cell growth.
IL-10TH2TH1Down-regulates TH1 cell production and secretions, inhibits macrophage function
IL-13TH2B CellIgE synthesis
TGF - BetaTH2, macrophages, mast cells, plateletsB CellClass switching IgM to IgA, inhibits activation of monocytes, and T-cells, active in wound healing
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Proinflammatory Cytokines
CytokineMajor SourceMajor Target CellsMajor Effects
IL-1MacrophageEndothelial CellsFever, Inflammation, Increased Vascular Permeability, proliferation of TH2 cells.
IL-6MacrophageT-Cell, B-CellT-cell activation, induces IL-2 production, Acute phase Protein synthesis, hematopoetic progenitor cell proliferation,
IL-8MacrophageNeutrophilChemotaxis
IL-12Macrophage, B cellsTH1, NK CellDevelopment (TH0 to TH1 CD4+ cells) and Activation of NK cells
TNF - AlphaMacrophage, NK Cells, Mast CellsEndothelial CellsInflammation/Toxicity, Activation of endothelial cells and other cells of the immune and non-immune systems, induces fever and septic shock
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Cytotoxic T-Cell Cytokines
CytokineMajor SourceMajor Target CellsMajor Effects
TNF - BetaCD8+ cells (CD cells)All nucleated cells displaying recognized complexKilling target cells
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Growth Factor Cytokines
CytokineMajor SourceMajor Target CellsMajor Effects
IL-3TH1Hematopoetic Stem CellsDiversification into myeloid progenitor cells
GMCSFMacrophageStem CellsProduce granulocytes (neutrophils, eosinophils, and basophils) and monocytes.
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