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CYP

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chilarkin's version from 2016-06-08 20:09

Section

Question Answer
1A2 inhibitorsFluvoxamine, ciprofloxacin, cimetidine, amiodarone, efavirenz, fluoroquinolones, interferon, ticlopidine
1A2 inducersCarbamazepine, insulin, modafinil, nafcillin, omeprazole, rifampin, tobacco
1A2 substratesAmitriptyline, caffeine, clomipramine, clozapine, cyclobenzaprine, duloxetine, estradiol, fluvoxamine, haloperidol, imipramine, mexiletine, nabumetone, naproxen, olanzapine, ondansetron, acetaminophen, propranolol, riluzole, ropivicaine, tacrine, theophylline, tizanidine, triamterene, verapamil, warfarin, zolmitriptan, zileuton
2B6 inhibitorsClopidogrel, thiotepa, ticlopidine, voriconazole
2B6 inducersArtemisinin, carbamazepine, efavirenz, nevirapine, phenobarbital, phenytoin, rifampin
2B6 substratesArtemisinn, bupropion, cyclophosphamide, efavirenz, ifosphamide, ketamine, methadone, nevirapine, propofol, selegiline,sorafenib
memorize

 

Question Answer
2C8 inhibitorsGemfibrozil, trimethoprim, glitazones, montelukast, quercetin
2C8 inducersRifampin
2C8 substratesAmiodaquine, cerivastatin, paclitaxel, repaglinide, sorafenib, torsemide
2C9 inhibitorsFluconazole, amiodarone, efavirenz, fenofibrate, fluconazole, fluvastatin, fluvoxamine, isoniazid, lovastatin, metronidazole, paroxetine, phenylbutazone, probenicid, sertraline, sulfamethoxazole, sulfaphenazole, teniposide, voriconazole, zafirlukast
2C9 inducersCarbamazepine, enzalutamide, nevirapine, phenobarbitol, rifampin, secobarbital, St. John's Wort
2C9 substratesNSAIDs, tolbutamide, glipizide, losartan, irbesartan, sulfonylureas, amitriptyline, celecoxib, fluoxetine, fluvastatin, nateglinide, phenytoin-4-OH2, rosiglitazone, tamoxifen, torsemide, valproic acid, s-warfarin, zakirlukast
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Question Answer
2C19 inhibitorsPPIs, chloramphenicol, cimetidine, felbamate, fluoxetine, fluvoxamine, indomethacin, isoniazid, ketoconazole, modafinil, OCP's, oxcarbazepine, probenicid, ticlopidine, topiramate, voriconazole
2C19 inducersCarbamazepine, efavirenz, enzalutamide, norethindrone, pentobarbital, prednisone, rifampicin, St. John's Wort
2C19 substratesPPIs, diazepam, phenytoin, phenobarbitone, amitriptyline, carisoprodol, citalopram, chloramphenicol, clomipramine, clopidogrel, cyclophosphamide, imipramine, nelfinavir, nilutamide, primidone, progesterone, propranolol, warfarin, voriconazole
memorize
2D6 inhibitors: bupropion, paroxetine, fluoxetine, quinidine, duloxetine, sertraline, terbinafine, amiodarone, cimetadine, chloroquine, cinacalcet, diphenhydramine, haloperidol, imatinib, propafenone, propoxyphene, thioridazine
2D6 inducers: mostly a genetic variation
2D6 substrates: amitriptyline, atomoxetine, carvedilol, chlorpheniramine, codeine, desipramine, dextromethorphan, dihydrocodeine, diphenhydramine, dolasetron, doxepin, duloxetine, flecainide, fluoxetine, fluvoxamine, haloperidol, hydrocodone, imipramine, maprotiline, metclopramide, metoprolol, mexilietine, nortriptyline, palonosetron, paroxetine, perhexiline, promethazine, propafenone, propranolol, protriptyline, risperidone, tamoxifen, thioridazine, timolol, tolterodine, tramadol, trazodone, venlafaxine