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CVD & CVD Studies

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bethdrysdale94's version from 2017-01-21 16:13

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Question Answer
What is CVD?disease of the heart and circulatory system including but not limited to atherosclerosis, MI, Stroke, AF, blah blah
How many deaths was CVD responsible for in 2014? (%)27% (BHF 2015)
What % of blood flow needs to be impeded by atherosclerosis in order to cause a problem?45%, leads to stroke, infarct, gangrene etc
Morris et al (1990) exercise and CHD study info9376 male civil servants, nearly 10 yr longitudinal study. exercise reported and split into vigorous/non-vigorous.
Morris et al (1990) study findingsoverall 474 MIs (over 50% fatal) however 9% who did significant physical activity had less than half of CHD than others. CHD/1000 man years higher in all with a risk factor. Vigorous activity group had reduced episodes of CHD despite having or not having a risk factor. (non-vigorous exercise was not protective of CHD)
Morris et al (1990) study strengths and limitationsself report bias. only males.
Barlow et al (2012) CVD and fitness study info11,190 aged 30-50, healthy. 27 years following, grouped into fitness quintiles based on VO2 max
Barlow et al (2012) study findings1 met increase in cardio fitness associated with 18% reduction in CVD mortality. 214 participants died due to CVD.
Barlow et al (2012) study strengths and weaknessesVO2 max over self report for fitness levels. longitudinal, large sample size, adjusted for age, gender BMI, etc. HOWEVER measure fitness at one point in time and expect that results are reflective of behaviour over time
Paffenbarger et al (1993) CHD risk and exercise whole studymen with increase from 1st-2nd fitness tests reduced CHD risk by 17%. men who went from moderate to vigorous reduced by 41% compared to control.
Blair et al (1995) exercise and CVD mortalityAerobics centre longitudinal study. unfit to fit = 52% in relative CVD mortaility
Katzmarzyk et al (2009) sitting time and CVD mortality17,013 canadians. 18-90yo. follow up average 12 years. 759 deaths from CVD
Katzmarzyk et al (2009) study findingsincreased sitting time = increased risk of CVD mortality
Katzmarzyk et al (2009) study strengths and limitationsvariables adjusted for. self report. large sample, large range
Khera et al (2016) atherosclerotic list and lifestyle study info7814 men and women in atherorisk. genetic risk based on 50 polymorphisms. genetic risk vs favourable lifestyle risk (no smoking, no obesity, regular PA and healthy diet)
Khera et al (2016) study findingsgenetic risk & lifestyle combined against 10yr coronary event. lowest risk = low genetic risk and favourable lifestyle. highest risk = high genetic risk and unfavourable lifestyle. regardless of genetic risk, favourable lifestyle reduced risk by around 50%
Khera et al (2016) study strengths and limitationsself report, already flagged as atherosclerotic risk in community
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