lolernie's version from 2015-11-04 08:14



Question Answer
Nubulin runs alongthe actin thin filaments
Belt/Zipper JunctionZonula Adherens, Cadherins to actin skele
Cell junction orderTight, Adherens, Desmosomes, Gap, Hemidesmo on bottom
Hemidesmosomes useCadherens & cytoskeletal elements (keratin)
Keratohyalin granules in what layerStratum granulosum
SpectrinHereditary Spherocytosis
Sickle Cell point mutationGlu to Val (hydroxyurea ups fetal Hb)
Leukocyte that's like a mast cellBasophil
Leukocyte that can lessen inflammationEosinophil - Histiminase, arylsulfatase
Platelet alpha and delta granulesa=coag&fibrinogin d=serotonin&crap&etc.
RabGTPase, V-snare, T-snare, SNAPClathrin, adaptin
familial Hypercholesterolemia mutation LDL mutation, no clathrin coated pit
Golgi Cop 1Retrograde
How Nuclearporins workNo motor, has docking sites for inbound transport of small things
Nuclearporin energyGTP hydrolysis
ParenchymaThe key elements of an organ essential to its functioning,
Actin bundled by fascin and fimbrin with TERMINAL WEB and myosin for contractMicrovilli
Tight junction akaOccludins (zona)
Focal adhesioncommunicate cell to basement uses integrin
desmosome moleculecadherin
Hemidesmosome moleculeintegrin
Just under tight junctionsadhesive belt made of cadherin, plaque, actin
Basement membrane =basal lamina + lamina reticularis
Carcinoma vs adenocarcinomaCancer w/ epithelial origin vs gland epithelial origin
Do fibroblasts move, divide, and make ground substnaceYes and make collagen fibers
AggrecanAggregate from cartilage, proteoglycan, mostly polysacharide (95%+)
FibronectinDimer made by fibroblasts marks migratory pathways for embryonic cells
LamininIn cell membrane, binds type 4 collagen to basement
Motor unitOne axon innervating 1+ muscle units
Intrafusal fibersConnective tissue capsule around muscle fiber detects tension
Red muscle fibersType 1, slow, good with myoglobin (red)
White muscle fibersType 2, fast (less myoglobin)
Red or white more mitochondriaRed. Slow and continuous, lipid droplets around too for b-oxid
Dystroglycan complexcentral role in linking the extracellular matrix with the actin cytoskeleton
Transverse portion of intercalated discsTransverse = Fascia&Macular adherentes
lateral portion of intercalated discsGap junctions
T-tubuleInvagination of cell, one per sarcomere (hence not on smooth)
gamma delta T cells in gut epithelium are part of what immunityinnate
Stellate cells are part of what tissue and secrete whatreticular tissue, secrete type 3 collagen scars, hold fats,
Lymph node cortex vs paracorexB cells vs T-cells(para, deeper)
reticular cells, RBCs, macrophages, lymphocytes, plasma cells, granulocytes in spleen Splenic cords
Splenic sinus basal laminanon-existant, easier passing in and out
lymphocyte progenitor cells originate inBone marrow. ALL OF THEM
Langerhans are mostly inspinosum layer (dendritic cells of epidermis)
Merkel cellStratum basale with melanocytes in epidermis. connect nerves, purpose unknown
Stratum Basale and spinosum are mostlyKeratinocytes (also merkel, melanocytes, langerhans)
Spinosum spiny becausemany desmosomes and dried out
What layer of epidermis are all organelles including heratohyalin granules lostLucidum
Dead fused cells layercorneum
Tonofibrils associated withepithelial keratinocyte desmosomes
Melanocyte tipsphagocytosed by keratinocytes to get dat melanin
Key melanogenesis enzymeTyrosinase (lack of causes albinism, basal/squamous carcinoma)
Dermal papillae correspond toFingerprints aka dermal ridges
Bowman's glandsIn lamina propria of olfactory organ, secrete watery fluid for solubilization of odorants
Odorant biochem pathwayG protein Golf, increase cAMP, Cation (Aa) channels, depolarize
Bronchioles > _________ > _________ > Alveolar ductsTerminal bronchioles, respiratory bronchioles
CLARA CELLSCuboidal, surfactant, unique to bronchioles. Can break up mucus, lysozyme
Region of transition between conducting/respiratory regionsRespiratory bronchioles
interaveolar septum containsbed of continuous capillaries
Type 1 alveolarSquamous
Type 2 pneumocyteseptal cells, make surfactant, precursor to type 1
Respiratory Distress syndrome caused byLack of surfactant
AggrecanMajor proteoglycan in cartilage - forms gel- STILL ALLOWS NUTRIENT DIFFUSION
Collagen to cartilage - Type 1 Collagen resistsWeight (in fibrocartilage)
Type 2 cartilage whereelastic cartilage like epiglottis
Articular cartilage key pointBad at repair since NO PERICHONDRIUM, good at sliding
Intervertebral disk cartilage typeType 1, weight, fibrocartilage
Unit of COMPACT boneosteon
Interstitial lamellae areleft over osteons after remodelling
What runs in haversian cannals and volkman canal (radial)blood vessels
Type of bone that's highly sensitive to hormonestrabecular/spongey
PTH chain of eventBind osteoBLAST, causing secretion of RANKL. RANK on osteoCLAST activated, increase calcium
PTH is around whenCalcium is low
Calcitriol receptorOsteoblast increases Ca by inhibiting bone formation
Calcitonin lowers elevated blood Ca byinhibit osteoclast bone binding
Fracture repairendochondral AND intramembranous bone formation unite broken ends with BONE CALLUS
Intramembranous bone formation makesflat bones from mesenchymal tissue (thickens long bones)
Endochondrial ossificationsmodel of cartilage, primary ossification center. long bones.