COMLEX shtuff

mhewett's version from 2016-08-19 15:44

Reportable diseases

Question Answer
What are they?Hepatitis A/B/C, HIV, syphilis, gonorrhea, MMR, chicken pox, TB, salmonella, shigella

Inheritance Patterns

Question Answer
X linked recessive"Obvious Females Will Often Give Her Boys Her x-Linked Disorders" -OTC def, Fabry, Wiskott, ocular albinism, G6PD def, hunter's, bruton, hemophilia A/B, lesch nyhan, duchenne (& becker)
Trinucleotide Repeats"TRy HUNTING for MY FRIED eggs (X)" -Huntington's, Myotonic dystrophy, Friedreich ataxia, fragile X syndrome
Trinucleotide repeat expansions"X-Girlfriend's First Aid Helped Ace My Test"
Autosomal Dominant(structural defect diseases, bad, uncommon) "DOMINANT Job Hunting" - dystrophies myotonic, osteogenesis imperfecta, Marfan's, intermittent porphyria, noonan's, APKD/achondroplasia, NFT, tuberous sclerosis, Job's Huntington's
Autosomal Recessiveenzyme deficiencies, common stuff

Patient Presentations

Question Answer
back pain, multiple radiolucencies, L5 fx, anemic, hypercalcemiamultiple myeloma
abdominal pain, ascites, hepatomegalyBudd-Chiari syndrome (posthepatic venous thrombosis)
newborn- crying, tremors, tachypnea, sneezing, irritability, diarrheaneonatal abstinence syndrome
atrophy of the mammillary bodiesWernicke encephalopathy
cherry-red spots on macula w/ NO hepatosplenomegalyTay Sachs
multiple colon polyps, osteomas/soft tissue tumors, impacted/supernumerary teethGardner syndrome (subtype of FAP)


Question Answer
teratogenic drugs"I Am Loving My Perfect Weird Vampire" - Isotretinoin, ACE inhibitors, Lithium, Methotrexate, Phenytoin, Warfarin, Valproate
lithiumebstein's anomaly, nephrogenic DI, hypothyroidism
phenytoinNTDs, orofacial clefts, microcephaly, nail or digit hypoplasia
isotretinoinmicrocephaly, thymic hypoplasia, small ears, hydrocephalus
methotrexatelimb & craniofacial abnormalities, NTDs, abortion
ACE inhibitorsrenal dysgenesis, oligohydramnios
warfarinnasal hypoplasia, stippled epiphysis

Most common causes

Question Answer
exudative tonsillitisviruses (EBV)
acute sinusitisviruses, streptococcus pneumoniae
otitis mediastreptococcus pneumoniae, H influenza
malignant otitis externapseudomonas aeruginosa
acute bronchitisrhinovirus
nosocomial (hospital acquired) pnaE.coli
nursing home pnaklebsiella pneumoniae
ICU pnapseudomonas aeruginosa
atypical pnamycoplasma pneumoniae
community acquired pnastreptococcus pneumoniae
infection of burnspseudomona aeruginosa
bacterial meningitis- neonatee.coli, strep agalactiae, listeria
bacterial meningitis- child & young adultsN meningitidis
bacterial meningitis- adultstrep pneumoniae
bacterial meningitis- immunocompromisedstrep pneumoniae
aseptic meningitis- summerenteroviruses (echovirus)
aseptic meningitis- winter/springmumps virus


Question Answer
rickets is due tovitamin D deficiency
3 yo w/ large non-mobile non-tender abd mass; inc serum and urine HVA and VMAneed to think neuroblastoma (most common tumor of adrenal MEDULLA in children); biopsy shows small blue cells with neurosecretory granules and Homer-Wright rosettes
bleeding disorder associated with hemarthrosishemophilia A (VIII), B (IX), or C (XI)
nonproductive cough, sore throat, myalgias, headachesthink atypical pneumonia
parasitic/helminthic infections cause an increase in what cell type?eosinophils
head trauma, dec Na, inc urine osmolalitySIADH (caused by elevated release of ADH from post pituitary)
pheochromocytomas are tumors of theadrenal medulla that secretes catecholamines
Conn's syndrome affects what part of the adrenal cortex?zona glomerulosa (secretes excess aldosterone)
Cushing's syndrome affects what part of the adrenal cortex?zona fasciculata (secretes excess cortisol)
organophosphate mechanisminhibition of acetylcholinesterase
most common cause of atypical pneumoniamycoplasma pneumonia