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COLLAGEN

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laracrystalo's version from 2015-06-11 18:46

Section

Question Answer
where does hydroxylation occur? RER
what does scurvy inhibit?hydroxylation in the RER
where does glycosylation occur? RER
what does osteogenesis imperfecta inhibit?problems forming the triple helix in the RER
where is vitamin C needed?hydroxylation in the RER
where is triple helix formed?RER
what does ehlers dances inhibit?crosslinking in the extracellular space
what does aging inhibit?decreased synthesis of collagen fibrils
where is copper needed?cross linking (copper containing lysyl oxidase)
what reflects collagen synthesis?glycine content
what amino acids are important here?glycine, proline, lysine
what desk Menkes disease inhibit?decreased copper so decreased activity of lysol oxidase and problems with cross linking in the extracellular space
collagen molecules spontaneously assembleextracellular space
cleavage of N and C pro collagen peptidasesextracellular space
tropocollagenextracellular space
cleavage of the N terminal signal peptideRER
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random and amino acid derivatives

Question Answer
fomepizole inhibitsalcohol dehydrogenase
disulfiram inhibitsacetaldehyde dehydrogenase
epinephrinephenylalanine and tyrosine
NEphenylalanine and tyrosine
DAphenylalanine and tyrosine
niacintryptophan
serotonintryptophan
melatonintryptophan
histaminehistidine
hemeglycine
GABAglutamate
glutathioneglutamate
ureaarginine
NOarginine
creatinearginine
enzyme defect in PKUphenylalanine hydroxylase
enzyme defect in maple syrup urinealpha ketoacid dehydrogenase
enzyme defect in alkaptonuriahomogentisate oxidase
enzyme defect in homocystinuriacystathione synthase
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