shevyatiwari's version from 2015-04-27 08:13


Question Answer
A macrolideF, a lincosamdie derived from Streptomycin lincolnesis
Lincomycin is the active drugF, the pro drug.
Binds to the 50S subunit of bacterial ribosomal RNAT
Bacteriostatic to GP cocci (not incl enterococci), and anaerobesT
A D zone test is to show cross reactivity between erythromycin and clindamycinF - if positive, tells clinician to avoid clindamycin as an inducible resistance is present
Most aerobic GNB are susceptibleF, most are inherently resistance
Activity against Capnocytophaga canimorsus, P acnes and T gondiiT
Resistance to clindamycin doesn't imply resistance to macrlodiesF - resistance to clindamycin generally confers resistance to macrlodies if erm coded enzymes are produced
Well absorbed and highly distributedT
Food affects absorptionF
Clindamycin phosphate is activeF - but rapidly hydrolysed to clindamycin
Half life of 2.4-3 hours in adult and 2.5-3.4 hours in childrenT
Half life increased in renal and hepatic failure - dose adjustments required for bothF - it is increased in both - dose adjustment only for hepatic failure
Metabolised by the liverT
Excreted primarily in the urine as the active drugF - excreted as mainly metabolites
Highly protein boundT,92-94%
C difficile reported in up to 10%T
BM suppression and renal failure are commonF, rare
Cat BT
Excreted in breast milkT
May inhibit tubocurare and pancuroniumF - may potentiate them. Clindamycin has shown neuromuscular blocking properties

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